單細胞分離

應用域：

FluidFM OMNIUM方便了單細胞水平的研究，尤其適合應用于醫療、單細胞生物學、單細胞質譜、單細胞基因編輯、藥物研發等域。

基本參數：

- 單細胞水平的顯微注射、提取、分離以及細胞粘附力測定，全過程通過軟件設置自動化完成；

- 全自動進行細胞核、細胞質定位注射；

- 軟件自動更換探針更換，無需手動加載；

- 樣品臺移動精度：XY軸不大于1 nm；Z軸不大于0.2nm；

- 探針力學控制：提供探針當前壓力值并繪制曲線；

- 配置高靈敏度液體微流控系統，流體壓力控制精度：±0.5 mbar；

設備點：

單細胞注射——快速、準確、低損傷

單細胞提取——微量、低創、準確

單細胞分離——直觀、簡單、低損

測試數據

肝細胞的微量注射

HeLa細胞的微量提取

CHO細胞的單細胞分離

納米光刻DAPI染料

發表文章

1. Akanksha J., Gilles G., Fátima S., Reto T., Zhisong H., Nicolas L., Fides Z., Antonius C., Simon S., Christoph H., Ryoko O., Malgorzata S., Makiko S., René H., Juliane K., Sophie M., Matthias P. Lutolf, J. & Barbara T. (2025) Morphodynamics of human early brain organoid development. Nature, volume 644, pages1010–1019.

2. Jinlei Y., Tianyi L, Pingping Z., Runsong C., Jing W., Siyuan P., Murong D., Boya Z., Weiliang L., Liying Y., Sichun Z., Xinrong Z. (2025). On-Valve μSFE-SFC-MS Enables Fast Analysis of Single Oocyte Lipidome. Analytical Chemistry 2025, 97, 34, 18726–18734.

3. Fahy, K., Kapishnikov, S., Donnellan, M., McEnroe, T., O'Reilly, F., Fyans, W., & Sheridan, P. (2024). Laboratory based correlative cryo-soft X-ray tomography and cryo-fluorescence microscopy. Correlative Light and Electron Microscopy V, 293.

4. Gangoso, E., Southgate, B., Bradley, L., Rus, S., Galvez-Cancino, F., McGivern, N., ... & Pollard, S. M. (2021). Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion. Cell, 184(9), 2454-2470.

5. Fahy, K., Weinhardt, V., Vihinen-Ranta, M., Fletcher, N., Skoko, D., Pereiro, E., ... & McEnroe, T. (2021). Compact Cell Imaging Device (CoCID) provides insights into the cellular origins of viral infections. JPhys Photonics, 3(3).

6. Kapishnikov, S., Hempelmann, E., Elbaum, M., Als‐Nielsen, J., & Leiserowitz, L. (2021). Malaria pigment crystals: The achilles′ heel of the malaria parasite. ChemMedChem, 16(10), 1515-1532.

7. Kapishnikov, S., Staals?, T., Yang, Y., Lee, J., Perez-Berna, A. J., Pereiro, E., ... & Als-Nielsen, J. (2019). Mode of action of quinoline antimalarial drugs in red blood cells infected by Plasmodium falciparum revealed in vivo. Proceedings of the National Academy of Sciences, 116(46), 22946-22952.

8. Kapishnikov, S., Leiserowitz, L., Yang, Y., Cloetens, P., Pereiro, E., Awamu Ndonglack, F., ... & Als-Nielsen, J. (2017). Biochemistry of malaria parasite infected red blood cells by X-ray microscopy. Scientific reports, 7(1), 802.

用戶單位

國內用戶單位

國外高校、研究所等科研機構：

國外生物醫藥研發機構：

?IRBM

?LGC - The Native Antigen Company (TNAC)

?AbbVie

?Almac Group