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TargetMol®Mini片段親電雜環庫
Since screening electrophilic fragments has become a promising alternative to discovering and verifying new targets and generating viable chemical starting points, we designed a Mini Electrophilic Heterocyclic Fragment Library. These compounds are basically covalent MiniFrags, containing five- and six-membered nitrogen-containing heterocycles with electron-withdrawing properties that can activate small electrophilic substituents (halogen, ethynyl, vinyl, and nitrile groups). The library contains not only small electrophilic heterocycles, but also N-quaternized analogs with increased reactivity. 371 compounds in total in the Highly Solubility Covalent Heterocyclic Fragment Library
 

TargetMol®Mini片段親電雜環庫Product Description

The theoretical basis of FBDD is to select favorable fragment combinations or extensions to obtain new drug molecules, with a higher probability of obtaining highly active drug candidates. Compared with the screening of millions of macromolecules, thousands of fragment molecules can be combined to form millions of drug structures, which are easier to collect and manage. In addition, fragments have smaller molecular weights, relatively higher solubility, and easier structural optimization. The potential of over-the-counter medicine is higher. Targeted covalent inhibitors and chemical probes have become part of drug discovery methods. Given the advantages of fragment-based drug discovery, screening electrophilic fragments has become a promising alternative to discover and verify new targets and generate viable chemical starting points, even for targets that are almost difficult to handle. In response to this situation, we designed a small library of heterocyclic electrophilic compounds.

General technology for covalent fragment screening ：

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品牌介紹：
TargetMol Chemicals Inc. 總部位于馬薩諸塞州波士頓，致力于為全球生化領域科學家的研究提供專業的產品和服務。TargetMol品牌的客戶群分布于40多個國家和地區，已發展成為豐富的化合物庫和小分子化合物研究供應商之一。

☆ TargetMol®品牌專業提供各領域信號通路小分子抑制劑、拮抗劑、天然產物、藥物篩選化合物。
☆ 產品適應在癌癥、免疫學、心血管系統、呼吸、神經科學等多項科學領域的研發使用，超過1180萬種小分子化合物。
☆ 提供20000多個小分子抑制劑、天然產物和200多個化合物庫。
☆ 配備*的化學合成和生物實驗室，可分別提供高品質小分子抑制劑和藥物篩選技術服務。
☆ 每批產品都有嚴格的NMR和HPLC技術檢測，以保證產品高純度高質量。