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TargetMol®高溶解性微型片段庫

The compound library of highly soluble micro-fragments consists of 1082 low-molecular-weight fragments. Low-molecular-weight compounds (so-called micro-fragments) are derived from commercially available fragment spaces. The focus is on ensuring the chemical stability of the compound, the absence of reactive compounds, meeting the physical and chemical characteristics of the screening, and not strictly complying with the drug similarity standards, the structural diversity of compounds/covering a wider chemical space, aims to provide hit drug targets for the fields of new drug discovery and drug design.
 

TargetMol®高溶解性微型片段庫Product Description

Traditional drug research and development are mainly based on natural active products or screening new drugs from existing compound data, but this method is highly random, blind, and inefficient. Medicinal chemists subsequently developed high-throughput screening (HTS) methods for drug discovery. Many pharmaceutical companies have also established compound libraries containing millions of small molecules and discovered many drug candidates. However, in drug screening with complex targets, HTS has been repeatedly frustrated. It is difficult to screen high-potential compounds, or the screened compounds have high false positives and poor drug-like properties. In this context, Fragment-based drug design (FBDD) came into being.

Feature：

1. The chemical properties are stable, the structure is diverse, and the chemical space is widely distributed;

2. Each fragment has been tested for solubility: DMSO (200 mM) and PBS (1 mM);

3. The molecular weight of most fragments is less than 300, and the number of hydrogen bond donors and acceptors is not higher than 3;

4. Strict quality control, and the purity of the compounds is above 95%;

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品牌介紹：
TargetMol Chemicals Inc. 總部位于馬薩諸塞州波士頓，致力于為全球生化域科學家的研究提供業的產品和服務。TargetMol品牌的客戶群分布于40多個國家和地區，已發展成為全球大的化合物庫和小分子化合物研究供應商之一。

☆ TargetMol®品牌業提供各域信號通路小分子抑制劑、拮抗劑、天然產物、藥物篩選化合物。
☆ 產品適應在癌癥、免疫學、心血管系統、呼吸、神經科學等多項科學域的研發使用，超過1180萬種小分子化合物。
☆ 提供20000多個小分子抑制劑、天然產物和200多個化合物庫。
☆ 配備*的化學合成和生物實驗室，可分別提供高品質小分子抑制劑和藥物篩選技術服務。
☆ 每批產品都有嚴格的NMR和HPLC技術檢測，以保證產品高純度高質量。