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• 提示：詳情請下載說明書。

• 產品描述： XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC50 of 3.4 nM, and also shows potent effect with IC50s of 215, 42 nM on CK2, PIM1, respectively, and an EC50 of 118 nM on pMCM.

• 靶點： Cdc7:3.4 nM (IC50);PIM1:42 nM (IC50);CK2:215 nM (IC50)

• 體內研究： XL413 (BMS-863233; 100 mg/kg, p.o.) hydrochloride shows excellent plasma exposures in mice and possesses good PK properties. XL413 (10, 30, or 100 mg/kg, p.o.) hydrochloride is well tolerated at all the doses, with no significant body weight loss

• 參考文獻：
  1. Koltun ES, et al. Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3727-31. 2. Sasi NK, et al. The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One. 2014 Nov 20;9(11):e113300.

• 溶解度： H2O  :  10  mg/mL  (30.66  mM;  Need  ultrasonic)    DMSO  :  3.4  mg/mL  (10.42  mM;  Need  ultrasonic  and  warming)

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	3.066 ml	15.329 ml	30.658 ml
  5 mM	0.613 ml	3.066 ml	6.132 ml
  10 mM	0.307 ml	1.533 ml	3.066 ml
  50 mM	0.061 ml	0.307 ml	0.613 ml

• 注意：部分產品我司僅能提供部分信息，我司不保證所提供信息的性，僅供客戶參考交流研究之用。