大黃素

分析標(biāo)準(zhǔn)品,HPLC≥98%

Emodin

CAS號(hào)：518-82-1

分子式：C15H10O5

分子量：270.24

MDL：MFCD00001207

產(chǎn)品介紹

熔點(diǎn)：255℃

沸點(diǎn)：586.9℃ at 760 mmHg

外觀：橙黃色長(zhǎng)針狀結(jié)晶(丙tong中結(jié)晶為橙色,甲醇中結(jié)晶為黃色)

溶解性：幾乎不溶于水，溶于乙醇及堿溶液。

敏感性：對(duì)光和空氣敏感

儲(chǔ)存條件：2-8℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(151篇)

151. [IF=3] Can Zhu et al."Pharmacological Evaluation of Polygoni Multiflori Radix Praeparata Extract: Inhibition of PANoptosis in Alleviating Premature Ovarian Insufficiency."CURRENT ISSUES IN MOLECULAR BIOLOGY.2025 Jul;47(7):569

150. [IF=4.1] Jiaqian Xue et al."Effects of Emodin on Lung Inflammation and Intestinal Microbes in Chronic Obstructive Pulmonary Disease."Journal of Inflammation Research.

149. [IF=5.4] Lihua Cui et al."Hu Gan Tang ameliorates metabolic-associated fatty liver disease by inhibiting ferroptosis through the Nrf2/GPX4 pathway."JOURNAL OF ETHNOPHARMACOLOGY.2025 Sep;353:120342

148. [IF=8.3] Liqun Jia et al."Wuse-oil Compound 03 Mitigates Radiation-Induced Oral Mucositis by Modulating Oral Microbiota to Mediate TLR4/NF-κB Pathway and Inhibit M1 Macrophage Polarization."PHYTOMEDICINE.2025 Jul;:157083

147. [IF=8.5] Xinyue Liu et al."Nitroreductase from Enterococcus faecalis catalyzes the metabolic activation of sennoside A in the colon via a unique CC reductive cleavage."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2025 Jun;:145153

146. [IF=1.7] Yu-Han Piao et al."Integrating Intestinal Biotransformation and Gut Microbiota to Uncover the Influence of Tongfu Xiexia Decoction in Rats With Constipation."RAPID COMMUNICATIONS IN MASS SPECTROMETRY.2025 May;39(15):e10065

145. [IF=8.5] Zengliu Song et al."Enhancing supersaturation maintenance of hydrophobic ingredients using nanostructured lipid carriers: The role of solid lipid type and level."FOOD CHEMISTRY.2025 Feb;465:142057

144. [IF=4.4] Chenxi Wang et al."Integrated chemical analysis, metabolic profiling, network pharmacology, molecular docking and toxicity prediction to reveal the active ingredients and their safety of raw and prepared rhubarbs in the treatment of gastric ulcers."Fronti

143. [IF=5.3] Zhang Wei et al."Metabolomics and proteomics analyses of Chrysanthemi Flos: a mechanism study of changes in proteins and metabolites by processing methods."Chinese Medicine.2024 Dec;19(1):1-19

142. [IF=3.1] Ping Zhao et al."Identification of anti-SARS-CoV-2 compounds from Qingwen Zhike prescription and exploration of their underlying mechanism by UPLC-Q-Exactive Orbitrap MS, high-throughput screening assays and transmission electron microscopy."JOURNAL OF PH

141. [IF=5.7] Lili Yang et al."Herbal HuoXueTongFu Formula with anti-inflammatory and fibrinolytic activity regulation for the prevention of postoperative peritoneal adhesions."Frontiers in Immunology.2025 Jan;15:

140. [IF=2.7] Yuan Xu et al."Hua Yu Xiao Zheng decoction induces ectopic endometrial stromal cell senescence via inhibiting the PI3K/AKT signaling."TISSUE & CELL.2025 Jan;:102763

139. [IF=4.2] Jiaoyue Zhu et al."Investigating the Formation and Molecular Solubilization Mechanism of Emodin Solid Dispersions by Molecular Dynamics Simulation."MOLECULES.2025 Jan;30(4):822

138. [IF=7.1] Jiahui Gong et al."Smart Dual-Responsive Ionic Liquid as Transformable and Recyclable Media for Extracting and Separating Phytochemicals from Wild Rumex acetosa L.."ACS Sustainable Chemistry & Engineering.2024;XXXX(XXX):XXX-XXX

137. [IF=6.7] Kaixin Liu et al."Polydatin mitigates thrombosis by inhibiting PHD2-induced proline hydroxylation on collagen, reducing platelet adhesion."PHYTOMEDICINE.2025 Mar;138:156392

136. [IF=4.7] Yijie Li et al."Anthraquinones of Cassiae Semen alleviate lipid accumulation in obesity by regulating brown adipose tissue and liver function."Chinese Herbal Medicines.2025 Feb;:

135. [IF=6.1] Jia Guo et al."Discovery of anthraquinones as potent Notum inhibitors for treating osteoporosis by integrating biochemical, phytochemical, computational, and experimental assays."Journal of Pharmaceutical Analysis.2025 Mar;:101256

134. [IF=4.8] Ke-han Chen et al."Evaluating the efficacy and safety of emodin, luteolin, and paeonol combination from Dahuang Mudan decoction in ameliorating ulcerative colitis."JOURNAL OF ETHNOPHARMACOLOGY.2025 Apr;346:119692

133. [IF=4.8] Chunying Li et al."A green and sustainable synthesis of polydopamine molecularly imprinted resin for selective recognition emodin in Rumex acetosa L.: experiments and simulation."Food Bioscience.2025 Apr;:106674

132. [IF=1.5] Qian Xiaojing et al."Qualitative, Quantitative Analysis and Pharmacokinetic Study of Potentially Active Components of Huangxueyishen Decoction Based on UPLC-MS/MS."JOURNAL OF CHROMATOGRAPHIC SCIENCE.2025 Apr;63(4):

131. [IF=4.3] Chenghao Zhang et al."Emodin nanocrystals enhanced mucus penetration and ameliorated bleomycin-induced pulmonary fibrosis by pulmonary delivery."JOURNAL OF DRUG TARGETING.

130. [IF=3.8] Haitao Wang et al."Combination of Metabolomics, Lipidomics, and Molecular Biology for the Investigation of the Metabolic Disturbance of Short-Term Administration of Emodin."JOURNAL OF PROTEOME RESEARCH.2024;23(10):4327–4342

129. [IF=6.6] Wenyu Zhang et al."Biomimetic Iron-Based Nanoparticles Remodel Immunosuppressive Tumor Microenvironment for Metabolic Immunotherapy."International Journal of Nanomedicine.

128. [IF=4.9] Xiaoran Zhao et al."Constructing a hydrogel based on self-assembly properties of glycyrrhizic acid: A drug delivery system with digestive tract responsive."COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS.2024 Sep;697:134497

127. [IF=8.5] Guangfu Feng et al."Natural Flavonoid-Derived Enzyme Mimics DHKNase Balance the Two-Edged Reactive Oxygen Species Function for Wound Healing and Inflammatory Bowel Disease Therapy.."Research.2024 Sep;7:0464-0464

126. [IF=1.3] Ze-Ye Tan et al."Correlation analysis between potential hepatotoxicity and ingredient content of polygoni multiflori caulis."JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH.

125. [IF=3.9] Xiong Weijian et al."Emodin inhibits M1 macrophage activation that related to acute and chronic kidney injury through EGFR/MAPK pathway."FUNCTIONAL & INTEGRATIVE GENOMICS.2024 Aug;24(4):1-13

124. [IF=5.3] Chuanxi Tian et al."Exploring the therapeutic efficacy: Unveiling the active compounds of Huashi Baidu granules against COVID-19."Arabian Journal of Chemistry.2024 Sep;17:105910

123. [IF=10.6] Hou Yu et al."Integrated oral microgel system ameliorates renal fibrosis by hitchhiking co-delivery and targeted gut flora modulation."JOURNAL OF NANOBIOTECHNOLOGY.2024 Dec;22(1):1-21

122. [IF=7.9] Huiyi Song et al."Emodin nanocapsules inhibit acute pancreatitis by regulating lipid metabolic reprogramming in macrophage polarization."PHYTOMEDICINE".2024 Jul;130:155763

121. [IF=3.9] Yibao Wei et al."Protective effects of emodin on subchondral bone and articular cartilage in osteoporotic osteoarthritis rats: A preclinical study."EXPERIMENTAL GERONTOLOGY".2024 Jun;190:112413

120. [IF=2] Lin Zhou et al."Therapeutic Potential of Danyankang Capsule in High-Fat Diet-Induced Cholelithiasis and Its Impact on Liver FXR Signaling and Gut Microbiota."BIOLOGICAL & PHARMACEUTICAL BULLETIN".2024 Mar;47(3):680-691

119. [IF=5.6] Tong Qingheng et al."Integrated chemical characterization, metabolite profiling, and pharmacokinetics analysis of Zhijun Tangshen Decoction by UPLC-Q/TOF-MS."Frontiers in Pharmacology".2024 Mar;15:

118. [IF=7.5] Yong-Guang Liu et al."Anti-inflammatory effect and pharmacokinetics of dehydroandrographolide, an active component of Andrographis paniculata, on Poly(I:C)-induced acute lung injury."BIOMEDICINE & PHARMACOTHERAPY".2024 May;174:116456

117. [IF=3.1] Liuxuan Yang et al."Biomimetic delivery of emodin via macrophage membrane-coated UiO-66-NH2 nanoparticles for acute pancreatitis treatment."BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS".2024 Apr;702:149649

116. [IF=4.3] Fan Xinyu et al."A comprehensive investigation on the chemical changes of traditional Chinese medicine with classic processing technology: Polygonum multiflorum under nine cycles of steaming and sunning as a case study."ANALYTICAL AND BIOANALYTICAL CHEMIS

115. [IF=4.9] Zhao Xia et al."Comparative transcriptome analysis and identification of candidate R2R3-MYB genes involved in anthraquinone biosynthesis in Rheum palmatum L.."Chinese Medicine".2024 Dec;19(1):1-18

114. [IF=4.1] Xiaoyao Liu et al."The Water Extract of Rhubarb Prevents Ischemic Stroke by Regulating Gut Bacteria and Metabolic Pathways."Metabolites".2024 Apr;14(4):216

113. [IF=2.7] Ding-Wen Cheng et al."Emodin inhibits HDAC6 mediated NLRP3 signaling and relieves chronic inflammatory pain in mice."Experimental and Therapeutic Medicine.2024 Jan;27(1):1-7

112. [IF=8.2] Yanli Wang et al."β-1,3-d-glucan particles-based “nest" protected co-loaded Rhein and Emodin regulates microbiota and intestinal immunity for ulcerative colitis treatment."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2023 Dec;:128818

111. [IF=8.8] Feng Xiong et al."Geographical verification of Pleuropterus multiflorus thunb. by functional compounds, stable isotope ratios, and multielement combined with machine learning methods."FOOD CHEMISTRY.2024 May;440:138209

110. [IF=4.8] Yan Lan et al."Polygonum Cuspidatum Alcohol Extract Exerts Analgesic Effects via the MAPK/ERK Signaling Pathway."Drug Design Development and Therapy.

109. [IF=4.5] Guangtao Pan et al."Dachengqi decoction ameliorates sepsis-induced liver injury by inhibiting the TGF-β1/Smad3 pathways."Journal of Traditional and Complementary Medicine.10.1016/j.jtcme.2023.09.001

108. [IF=2.9] Qi Ying et al."Sanhuang Xiexin Decoction Ameliorates TNBC By Modulating JAK2-STAT3 and Lipid Metabolism."Chinese Journal of Integrative Medicine.2023 Nov;:1-10

107. [IF=3.4] Si Li et al."Active ingredients of Erhuang Quzhi Granules for treating non-alcoholic fatty liver disease based on the NF-κB/NLRP3 pathway."FITOTERAPIA.2023 Dec;171:105704

106. [IF=5.4] Bo Zhang et al."Integration of single-nucleus RNA sequencing and network disturbance to elucidate crosstalk between multicomponent drugs and trigeminal ganglia cells in migraine."JOURNAL OF ETHNOPHARMACOLOGY.2024 Jan;319:117286

105. [IF=3.2] Zhongjie Hua et al."Emodin protects against intestinal dysfunction and enhances survival in rat model of septic peritonitis through anti-inflammatory actions."Immunity Inflammation and Disease.2023 Aug;11(8):e942

104. [IF=10.2] Lei Fenting et al."Oral hydrogel nanoemulsion co-delivery system treats inflammatory bowel disease via anti-inflammatory and promoting intestinal mucosa repair."JOURNAL OF NANOBIOTECHNOLOGY.2023 Dec;21(1):1-19

103. [IF=3.1] Cuicui Liu et al."Identification and quantitative analysis of the chemical constituents of Gandouling tablets using ultra-high-performance liquid chromatography with quadrupole time-of-flight mass spectrometry."JOURNAL OF SEPARATION SCIENCE.2023 Jun;:2300

102. [IF=5.4] Jie Tang et al."Study on the mechanism of Shuganzhi Tablet against nonalcoholic fatty liver disease and lipid regulation effects of its main substances in vitro."JOURNAL OF ETHNOPHARMACOLOGY.2023 Nov;316:116780

101. [IF=7.3] Li Chen et al."Emodin promotes hepatic stellate cell senescence and alleviates liver fibrosis via Nur77-mediated epigenetic regulation of GLS1."BRITISH JOURNAL OF PHARMACOLOGY.2023 Jun;:

100. [IF=8.2] Jia Wan et al."Chitosan-based double network hydrogel loading herbal small molecule for accelerating wound healing."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2023 Aug;246:125610

99. [IF=3.776] Lele Zhang et al."Integration of UHPLC/Q-OrbitrapMS-based metabolomics and activities evaluation to rapidly explore the anti-inflammatory components from lasianthus.."Heliyon.2023 May;9(6):e16117-e16117

98. [IF=4.601] Yuexuan Li et al."Facile and selective separation of anthraquinones by alizarin-modified iron oxide magnetic nanoparticles."JOURNAL OF CHROMATOGRAPHY A.2023 Aug;1702:464088

97. [IF=3.242] Xu Chenyu et al."The active compound in Rheum officinale Baill, aloe-emodin promotes tomato seedling growth."PLANT GROWTH REGULATION.2023 Mar;:1-14

96. [IF=3.614] Liqing Wang et al."Discovery of the potential neuraminidase inhibitors from Polygonum cuspidatum by ultrafiltration combined with mass spectrometry guided by molecular docking."JOURNAL OF SEPARATION SCIENCE.2023 Mar;:2200937

95. [IF=6.656] Yanchao Xing et al."Cytochrome P450-mediated herb-drug interaction (HDI) of Polygonum multiflorum Thunb. based on pharmacokinetic studies and in vitro inhibition assays."PHYTOMEDICINE.2023 Feb;:154710

94. [IF=3.37] Dingwen Cheng et al."Emodin Alleviates Arthritis Pain through Reducing Spinal Inflammation and Oxidative Stress."Molecular Pain.

93. [IF=6.656] Chong Chen et al."Yishen-Qingli-Huoxue Formula attenuates renal fibrosis by inhibiting indoxyl sulfate via AhR/snai1 signaling."PHYTOMEDICINE.2022 Nov;:154546

92. [IF=3.571] Lin Zhou et al."Comprehensive investigation on the metabolism of emodin both in vivo and in vitro."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2023 Jan;223:115122

91. [IF=3.614] Li Ji et al."Characterization of the chemical constituents and metabolic profile of Polygonum cuspidatum Sieb. et Zucc. in rat plasma, urine, and feces by ultra-high performance liquid chromatography coupled with Quadrupole-Exactive Orbitrap mass spectrom

90. [IF=3.645] Xi Zhou et al."Preparation of magnetic metal-organic framework MIL-101(Fe) and its application in the extraction of anthraquinones in rhubarb."JOURNAL OF SEPARATION SCIENCE

89. [IF=4.36] Zhenhui Guo et al."Study on the mechanism of Cortex Lycii on lung cancer based on network pharmacology combined with experimental validation."J Ethnopharmacol. 2022 Apr;:115280

88. [IF=5.811] Kong  Wei-Song et al."Beware of the Potential Risks for Polygoni Multiflori Caulis-Induced Liver Injury."Front Pharmacol. 2022 Apr;0:928

87. [IF=4.432] Yanqing Wang et al.Emodin prevents renal ischemia-reperfusion injury via suppression of CAMKII/DRP1-mediated mitochondrial fission.Eur J Pharmacol. 2021 Nov;:174603

86. [IF=6.165] Yaofen Li et al.Study on the effects of deep eutectic solvents as a reaction media on the micromorphology of hydrogen-substituted graphyne and its adsorption and electrochemical properties.J Mol Liq. 2021 Nov;:118177

85. [IF=0.986] Ji-le Lan et al."Q-marker Prediction Analysis of Rhubarb in Fengyin Decoction Based on Fingerprint and Network Pharmacology:."Nat Prod Commun. 2021;16(8):

84. [IF=1.618] Tao Yi et al."Simultaneous Quantitation of Five Bioactive Ingredients in Raw and Processed Fallopia multiflora by Employing UHPLC-Q-TOF-MS."J Chromatogr Sci. 2019 Aug;57(7):618-624

83. [IF=1.902] Chenxi Wang et al."Multiple component-pharmacokinetic studies on 10 bioactive constituents of Peiyuan Tongnao capsule using parallel reaction monitoring mode."Biomed Chromatogr. 2021 Oct;35(10):e5153

82. [IF=2.161] Jinjing Li et al."Enhanced hydrophilicity and antifouling performance of PES-C/emodin ultrafiltration membrane:."High Perform Polym. 0;():

81. [IF=2.401] Yongqian  Huang et al."The intervention mechanism of emodin on TLR3 pathway in the process of central nervous system injury caused by herpes virus infection."Neurol Res. 2021;43(4):307-313

80. [IF=3] Qu  Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950

79. [IF=3.205] Jie Tang et al."Metabolite profiling of Shuganzhi tablets in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry."J Chromatogr B. 2021 Aug;1179:122827

78. [IF=3.882] Kunpeng Yin et al."Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine."Langmuir. 2021;37(17):5321–5328

77. [IF=3.935] Zhengchao Ji et al."Global identification and quantitative analysis of representative components of Xin-Nao-Kang Capsule, a traditional Chinese medicinal formula, by UHPLC-Q-TOF-MS and UHPLC-TQ-MS."J Pharmaceut Biomed. 2021 May;198:114002

76. [IF=3.935] Li Xie et al."Development of an UHPLC-MS/MS method for comparative pharmacokinetics of nine anthraquinones in rats and application to dosage conversion between different Semen Cassiae forms."J Pharmaceut Biomed. 2019 Sep;174:696

75. [IF=3.935] Yanchao Xing et al."An effective strategy for distinguishing the processing degree of Polygonum multiflorum based on the analysis of substance and taste by LC-MS, ICP-OES and electronic tongue."J Pharmaceut Biomed. 2021 Oct;205:114328

74. [IF=3.943] Yuanyuan Liu et al."Emodin ameliorates ovalbumin-induced airway remodeling in mice by suppressing airway smooth muscle cells proliferation."Int Immunopharmacol. 2020 Nov;88:106855

73. [IF=4.092] Shen  Pan et al."Emodin Attenuates Acetaminophen-Induced Hepatotoxicity via the cGAS-STING Pathway."Inflammation. 2021 Aug;:1-14

72. [IF=4.142] Wang  Chenxi et al."Systematic quality evaluation of Peiyuan Tongnao capsule by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry and adjusted parallel reaction monitoring of quality markers."Anal Bioanal Chem. 2019 Nov;4

71. [IF=4.36] Li Lin et al."Study on the protection of water extracts of Polygoni Multiflori Radix and Polygoni Multiflori Radix Praeparata against NAFLD and its mechanism."J Ethnopharmacol. 2020 Apr;252:112577

70. [IF=4.759] Yi Zhang et al."Screening of inhibitors against histone demethylation jumonji domain-containing protein 3 by capillary electrophoresis."J Chromatogr A. 2020 Feb;1613:460625

69. [IF=4.759] Yueping Jiang et al."Application of multifold characteristic ion filtering combined with statistical analysis for comprehensive profiling of chemical constituents in anti-renal interstitial fibrosis I decoction by ultra-high performance liquid chromatogra

68. [IF=5.645] Li-Xia Dai et al."Ultrasound-assisted extraction of five anthraquinones from Rheum palmatum water extract residues and the antimicrobial activities."Ind Crop Prod. 2021 Apr;162:113288

67. [IF=5.81] Zhihui Yin et al."Rhein Relieves Oxidative Stress in an Aβ1-42 Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis."Front Pharmacol. 2021; 12: 746711

66. [IF=5.81] Zhang N et al."Emodin Inhibits the Proliferation of MCF-7 Human Breast Cancer Cells Through Activation of Aryl Hydrocarbon Receptor (AhR).."Front Pharmacol. 2020 Jan;11:622046-622046

65. [IF=6.165] Neng Qiu et al."Inclusion complex of emodin with hydroxypropyl-β-cyclodextrin: Preparation, physicochemical and biological properties."J Mol Liq. 2019 Sep;289:111151

64. [IF=9.811] Manjie Gao et al."High-Crystallinity Covalent Organic Framework Synthesized in Deep Eutectic Solvent: Potentially Effective Adsorbents Alternative to Macroporous Resin for Flavonoids."Chem Mater. 2021;33(20):8036–8051

63. [IF=1.773] Li-Hua ZHOU et al."Label-free quantitative proteomics reveals fibrinopeptide B and heparin cofactor II as potential serum biomarkers in respiratory syncytial virus-infected mice treated with Qingfei oral liquid formula."Chin J Nat Medicines. 2018 Apr;16:2

62. [IF=1.843] Ma  Libin et al."Emodin ameliorates renal fibrosis in rats via TGF-β1/Smad signaling pathway and function study of Smurf 2."Int Urol Nephrol. 2018 Feb;50(2):373-382

61. [IF=3.361] Lailai Li et al."Development of a dual screening strategy to identify pro-angiogenic compounds from natural products: application on Tongmai Yangxin Pills."Rsc Adv. 2016 Dec;6(116):115308-115316

60. [IF=3.366] Wu  Xingqiang et al."A Novel Selective Accelerated Solvent Extraction for Effective Separation and Rapid Simultaneous Determination of Six Anthraquinones in Tartary Buckwheat and Its Products by UPLC–DAD."Food Anal Method. 2015 May;8(5):1124-1132

59. [IF=3.738] Selma Houchi et al."Investigation of common chemical components and inhibitory effect on GES-type β-lactamase (GES22) in methanolic extracts of Algerian seaweeds."Microb Pathogenesis. 2019 Jan;126:56

58. [IF=4.366] Longfei Lin et al."Inhibition of Mitochondrial Complex Function—The Hepatotoxicity Mechanism of Emodin Based on Quantitative Proteomic Analyses."Cells-Basel. 2019 Mar;8(3):263

57. [IF=4.411] Yanling Zeng et al."Rapid Characterization of Components in Bolbostemma paniculatum by UPLC/LTQ-Orbitrap MSn Analysis and Multivariate Statistical Analysis for Herb Discrimination."Molecules. 2018 May;23(5):1155

56. [IF=4.743] Hua  Jun-yi et al."Emodin prevents intima thickness via Wnt4/Dvl-1/β-catenin signaling pathway mediated by miR-126 in balloon-injured carotid artery rats."Exp Mol Med. 2015 Jun;47(6):e170-e170

55. [IF=5.64] Wu  Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466

54. [IF=5.645] Fangyuan Gao et al."Cyclodextrin-based ultrasonic-assisted microwave extraction and HPLC-PDA-ESI-ITMSn separation and identification of hydrophilic and hydrophobic components of Polygonum cuspidatum: A green, rapid and effective process."Ind Crop Prod. 20

53. [IF=9.229] Qing-Shan Liu et al."Novel Beta-Tubulin-Immobilized Nanoparticles Affinity Material for Screening β-Tubulin Inhibitors from a Complex Mixture."Acs Appl Mater Inter. 2017;9(7):5725–5732

52.  Zhou, Li-Hua, et al. "Label-free quantitative proteomics reveals fibrinopeptide B and heparin cofactor II as potential serum biomarkers in respiratory syncytial virus-infected mice treated with Qingfei oral liquid formula." Chin J Nat Med 16 (2018): 241-25

51.  Zhou, Li-Hua, et al. "Label-free quantitative proteomics reveals fibrinopeptide B and heparin cofactor II as potential serum biomarkers in respiratory syncytial virus-infected mice treated with Qingfei oral liquid formula." Chin J Nat Med 16 (2018): 241-25

50.  Huang, Xiya, Weixi Cai, and Baojun Xu. "Kinetic changes of nutrients and antioxidant capacities of germinated soybean (Glycine max L.) and mung bean (Vigna radiata L.) with germination time." Food chemistry 143 (2014): 268-276.https:##doi.org/10.1016/j.foo

49.  LIU, Qing-Shan, et al. Novel Beta-Tubulin-Immobilized Nanoparticles Affinity Material for Screening β-Tubulin Inhibitors from a Complex Mixture. ACS applied materials & interfaces, 2017, 9.7: 5725-5732.https:##doi.org/10.1021/acsami.6b13477

48.  Zhang, Ning, et al. "Emodin inhibits the proliferation of human breast cancer MCF-7 cells through activation of aryl hydrocarbon receptor." Frontiers in Pharmacology 11 (2020): 2372.https:##doi.org/10.3389/fphar.2020.622046

47.  Qiu, Neng, et al. "Inclusion complex of emodin with hydroxypropyl-β-cyclodextrin: Preparation, physicochemical and biological properties." Journal of Molecular Liquids 289 (2019): 111151.https:##doi.org/10.1016/j.molliq.2019.111151

46.  Lin, Longfei, et al. "Inhibition of Mitochondrial Complex Function—The Hepatotoxicity Mechanism of Emodin Based on Quantitative Proteomic Analyses." Cells 8.3 (2019): 263.https:##doi.org/10.3390/cells8030263

45.  Huang, Yongqian, et al. "The intervention mechanism of emodin on TLR3 pathway in the process of central nervous system injury caused by herpes virus infection." Neurological Research 43.4 (2021): 307-313.https:##doi.org/10.1080/01616412.2020.1853989

44.  Wang, Qi, et al. "Identification and characterization of the structure–activity relationships involved in UGT1A1 inhibition by anthraquinone and dianthrone constituents of Polygonum multiflorum." Scientific reports 7.1 (2017): 1-9.

43.  Gao, Fangyuan, et al. "Cyclodextrin-based ultrasonic-assisted microwave extraction and HPLC-PDA-ESI-ITMSn separation and identification of hydrophilic and hydrophobic components of Polygonum cuspidatum: A green, rapid and effective process." Industrial Cro

42.  張明明. 大黃道地產(chǎn)區(qū)核心種質(zhì)構(gòu)建及優(yōu)良種質(zhì)篩選研究[D].北京中醫(yī)藥大學(xué),2020.

41.  汪穎舒,朱廣灝,王冰,李杰榮,駱前飛,何修瀅,趙佳逸,修彥鳳.古法黑豆蒸曬與藥典黑豆汁連續(xù)蒸對(duì)何首烏中12個(gè)成分含量的影響[J].中草藥,2020,51(19):4972-4982.

40.  王盼,儲(chǔ)全根,軒云,蔡正銀.抵當(dāng)陷胸湯HPLC-MS指紋圖譜研究[J].時(shí)珍國(guó)醫(yī)國(guó)藥,2020,31(12):2937-2940.

39.  李承浩,王萌,任曉亮.磺化杯6芳烴對(duì)4類中藥單體成分增溶作用及其機(jī)制研究[J].中國(guó)現(xiàn)代中藥,2020,22(12):2032-2038.

38.  佘瑤瑤,劉自華,張穎,劉義梅,陳運(yùn)中.湖北虎杖主要化學(xué)成分的含量分析及其與色差的相關(guān)性研究[J].食品安全質(zhì)量檢測(cè)學(xué)報(bào),2021,12(03):960-967.

37.  周桂,謝瑞芳,于天源,周昕.首烏藤指紋圖譜的建立及3種成分的測(cè)定[J].中醫(yī)藥導(dǎo)報(bào),2020,26(13):27-32.

36.  寧一博,程龍,黃芷棋,賀潤(rùn)鋮,孫建寧,董世芬.基于脂肪棕色化探究大黃素對(duì)老齡小鼠脂質(zhì)代謝的影響[J].中南藥學(xué),2021,19(03):478-483.

35.  陸杰,王婷婷,梁琨,安叡,王新宏,陳穎.UPLC-LTQ-Orbitrap-MS法分析大承氣湯化學(xué)成分[J].中成藥,2020,42(12):3275-3280.

34.  陳靜.pH響應(yīng)的銅-大黃素脂質(zhì)體的制備及其體外釋放研究[J].江蘇科技信息,2020,37(31):52-54.

33.  周軍, 彭媚, 陳薇,等. 藥用虎杖剩余物的化學(xué)組成與熱解特性[J]. 環(huán)境工程學(xué)報(bào), 2018, 12(12):229-237.

32.  劉全德,唐仕榮,宋慧,王營(yíng),邢洪偉.蘆薈蒽醌類化合物的超聲提取及其抗氧化性研究[J].食品與機(jī)械,2011,27(05):68-71.

31.  郭允, 陳永超, 李曉花,等. 牛黃解毒片中6種指標(biāo)成分的含量測(cè)定[J]. 沈陽藥科大學(xué)學(xué)報(bào), 2016(6):454-458.

30.  楊強(qiáng)  蒲曉輝  李曉花. 一清膠囊中7種指標(biāo)成分的測(cè)定[J]. 華西藥學(xué)雜志  2017(3).

29.  李曉花 郭允 李佳 袁琦 蒲曉輝 王高峰.RP-HPLC法同時(shí)測(cè)定三黃片中7種指標(biāo)成分的含量[J].沈陽藥科大學(xué)學(xué)報(bào) 2016 33(08):637-642.

28.  魏艷婷  張靜宜  張華潭 等. HPLC法同時(shí)測(cè)定三黃滴丸中5種蒽醌類成分的含量[J]. 中國(guó)藥房  2015.

27.  程素盼  張敏敏  梁琰 等. HPLC-DAD-ESI-TOF/MS法分析安神補(bǔ)腦液中化學(xué)成分[J]. 中成藥  2019  041(004):743-748.

26.  李紅英  向極釬  龍瀾 等. HPLC法測(cè)定大黃藥材中5種游離蒽醌的含量[J]. 安徽農(nóng)業(yè)科學(xué)  2013(12):5278-5279.

25.  徐艷, 張心怡, 狄留慶,等. 基于熱熔擠出技術(shù)的虎杖提取物速釋固體分散體制備研究[J]. 中草藥, 2017(23):4865-4871.

24.  周楊靜,唐俊峰,高峰,衛(wèi)培峰.基于“九蒸九曬"炮制法的何首烏主要化學(xué)成分含量變化及對(duì)大鼠肝臟的影響實(shí)驗(yàn)研究[J].中南藥學(xué),2020,18(04):543-548.

23.  楊國(guó)靜  張珞琪  陳隨清 等. 不同商品規(guī)格決明子的質(zhì)量分析[J]. 中國(guó)現(xiàn)代中藥  2018  v.20(08):963-967.

22.  支旭然  劉洪濤  吳茵 等. UPLC-MS/MS法同時(shí)測(cè)定腎康注射液中7個(gè)有效成分[J]. 藥物分析雜志  2017  037(001):37-42.

21.  支旭然, 白萬軍, 王祁民,等. 腎康注射液的配伍穩(wěn)定性考察[J]. 中國(guó)藥師, 2016, 19(011):2155-2157.

20.  林艷, 劉月新, 李春,等. 生/制何首烏HPLC指紋圖譜結(jié)合模式識(shí)別與含量測(cè)定的質(zhì)量控制研究[J]. 中國(guó)中醫(yī)藥信息雜志, 2018, 25(12):67-71.

19.  王亞洲, 吳洪文. 燙傷合劑質(zhì)量標(biāo)準(zhǔn)研究[J]. 中國(guó)醫(yī)院藥學(xué)雜志, 2012, 32(021):1767-1769.

18.  蔡芳, 任繁棟, 任達(dá)兵,等. 整合定性策略用于大黃素代謝物的高通量靶向鑒定[J]. 分析化學(xué), 2019, 047(008):1212-1218.

17.  李宵  吳茵  支旭然 等. UPLC-MS/MS法同時(shí)測(cè)定苦黃注射液中7種成分的含量[J]. 中國(guó)藥房  2017  028(015):2108-2112.

16.  支旭然  董占軍  吳茵 等. HPLC同時(shí)測(cè)定腎康注射液中的4種成分[J]. 華西藥學(xué)雜志  2017(03):297-299.

15.  張蕾, 郭晏華, 黃婷,等. 虎杖生品及不同炮制品中虎杖苷、白藜蘆醇和大黃素含量[J]. 遼寧中醫(yī)藥大學(xué)學(xué)報(bào), 2013, 015(011):56-59.

14.  顧玲, 閆璟, 柯苗,等. 蘆丁在聚大黃素/納米氧化鋅修飾碳糊電極上的電化學(xué)行為研究[J]. 化學(xué)研究與應(yīng)用, 2017(10).

13.  李成職, 劉洋, 劉小紅,等. 消痔方醇提工藝和顆粒制劑含量測(cè)定方法[J]. 青島大學(xué)學(xué)報(bào)(工程技術(shù)版), 2018, 033(001):130-134.

12.  張丹參, 梅艷飛, 宋曉敏,等. 大黃結(jié)腸靶向微丸的制備及處方優(yōu)化[J]. 中草藥, 2016, 47(008):1321-1326.

11.  張丹參, 梅艷飛, 宋曉敏,等. 大黃結(jié)腸靶向微丸在大鼠胃腸道內(nèi)的分布及釋放方法學(xué)研究[J]. 神經(jīng)藥理學(xué)報(bào), 2015, 5(005):20-27.

10.  趙滋苗, 蔡宛如, 陸軍,等. 大黃素對(duì)膿毒癥大鼠血糖和胰島素抵抗的影響[J]. 中國(guó)現(xiàn)代應(yīng)用藥學(xué), 2016, 33(009):1115-1118.

9.  韋美金,黃娟,白俊其,蔡錫潮,丘小惠.大黃素對(duì)大鼠血清肝功能、肝臟轉(zhuǎn)運(yùn)蛋白及代謝酶UGT1A1表達(dá)的影響[J].時(shí)珍國(guó)醫(yī)國(guó)藥,2018,29(07):1551-1555.

8.  豆穎, 閆哲, 潘翔珍,等. 大黃素對(duì)口腔鱗癌細(xì)胞Tca8113抑制作用[J]. 醫(yī)藥論壇雜志, 2015(01):72-74.

7.  郝宗艷, 李欣, 李玲. 大黃素對(duì)功能性消化不良大鼠相關(guān)指標(biāo)影響的實(shí)驗(yàn)研究[J]. 新中醫(yī), 2017, 049(005):1-3.

6.  王云龍, 郭海, 魏睦新. 大黃素對(duì)CCl4誘導(dǎo)小鼠肝纖維化的作用機(jī)制[J]. 中國(guó)現(xiàn)代中藥, 2018, 20(04):402-408.

5.  李靈玲, 蒲吉, LI,等. 大黃素促進(jìn)結(jié)腸癌細(xì)胞自噬性凋亡的作用及其機(jī)制[J]. 華西藥學(xué)雜志, 2017, 06(v.32):46-49

4.  江坤, 李璐, 李菁,等. 基于抗炎藥效的中藥榕須質(zhì)量評(píng)價(jià)研究[J]. 中國(guó)藥學(xué)雜志, 2016, 051(012):1033-1038.

3.  孟雨婷, 李華, 陳志穎,等. 基于成分檢測(cè)的大黃-蜇蟲藥對(duì)最佳配伍比例的研究[J]. 遼寧化工, 2020, v.49;No.459(01):32-36.

2.  葛朝亮 程鋼 余劍萍 許杜娟.“九蒸九曬"傳統(tǒng)炮制對(duì)何首烏主要化學(xué)成分的影響[J].現(xiàn)代中藥研究與實(shí)踐 2017 31(03):43-47.

1.  陳帥  王慧竹  薛健飛 等. HPLC-DAD法同時(shí)測(cè)定四季三黃丸中9種成分[J]. 中成藥  2016(8期):1727-1731.

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