大黃酚

分析標準品,HPLC≥98%

Chrysophanol

CAS號：481-74-3

分子式：C15H10O4

分子量：254.24

MDL：MFCD00001208

產品介紹

熔點：194-198℃

沸點：489.5℃at760mmHg

外觀：金黃色結晶

溶解性：幾乎不溶于水,  DMSO：1mg/ml。

儲存條件：2-8℃

注意：部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(55篇)

55. [IF=4.8] Xuan Gou et al."Chrysophanol promotes M2 polarization and inhibits M1 polarization through the NF-κB signaling pathway to attenuate sepsis-associated acute kidney injury."Frontiers in Pharmacology.2025 Jul;16:

54. [IF=4.4] Chenxi Wang et al."Integrated chemical analysis, metabolic profiling, network pharmacology, molecular docking and toxicity prediction to reveal the active ingredients and their safety of raw and prepared rhubarbs in the treatment of gastric ulcers."Fronti

53. [IF=4.8] Feng-lin Zhang et al."Huashi baidu granule alleviates inflammation and lung edema by suppressing the NLRP3/caspase-1/GSDMD-N pathway and promoting fluid clearance in a porcine reproductive and respiratory syndrome (PRRS) model."JOURNAL OF ETHNOPHARMACOLOG

52. [IF=7.1] Jiahui Gong et al."Smart Dual-Responsive Ionic Liquid as Transformable and Recyclable Media for Extracting and Separating Phytochemicals from Wild Rumex acetosa L.."ACS Sustainable Chemistry & Engineering.2024;XXXX(XXX):XXX-XXX

51. [IF=6.7] Kaixin Liu et al."Polydatin mitigates thrombosis by inhibiting PHD2-induced proline hydroxylation on collagen, reducing platelet adhesion."PHYTOMEDICINE.2025 Mar;138:156392

50. [IF=5.7] Lili Yang et al."Herbal HuoXueTongFu Formula with anti-inflammatory and fibrinolytic activity regulation for the prevention of postoperative peritoneal adhesions."Frontiers in Immunology.2025 Jan;15:

49. [IF=6.1] Jia Guo et al."Discovery of anthraquinones as potent Notum inhibitors for treating osteoporosis by integrating biochemical, phytochemical, computational, and experimental assays."Journal of Pharmaceutical Analysis.2025 Mar;:101256

48. [IF=4.8] Chunying Li et al."A green and sustainable synthesis of polydopamine molecularly imprinted resin for selective recognition emodin in Rumex acetosa L.: experiments and simulation."Food Bioscience.2025 Apr;:106674

47. [IF=1.4] Sunghanghwa Yuwathida et al."Plasmodium falciparum Lactate Dehydrogenase Inhibitory Activities of Pomegranate and Mangosteen Extracts and their Major Constituents."Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy.2024 Jul;:1-10

46. [IF=5.3] Chuanxi Tian et al."Exploring the therapeutic efficacy: Unveiling the active compounds of Huashi Baidu granules against COVID-19."Arabian Journal of Chemistry.2024 Sep;17:105910

45. [IF=4.1] Xiaoyao Liu et al."The Water Extract of Rhubarb Prevents Ischemic Stroke by Regulating Gut Bacteria and Metabolic Pathways."Metabolites".2024 Apr;14(4):216

44. [IF=2] Lin Zhou et al."Therapeutic Potential of Danyankang Capsule in High-Fat Diet-Induced Cholelithiasis and Its Impact on Liver FXR Signaling and Gut Microbiota."BIOLOGICAL & PHARMACEUTICAL BULLETIN".2024 Mar;47(3):680-691

43. [IF=2.5] Wei Huang et al."Neuroprotective effect of chrysophanol in Alzheimer disease via modulating the Ca2+/EGFR-PLCγ pathway."NEUROSCIENCE LETTERS".2024 Feb;824:137684

42. [IF=4.9] Zhao Xia et al."Comparative transcriptome analysis and identification of candidate R2R3-MYB genes involved in anthraquinone biosynthesis in Rheum palmatum L.."Chinese Medicine".2024 Dec;19(1):1-18

41. [IF=3.6] Zhang Xiao-yan et al."Network pharmacology-based approach to understand the effect and mechanism of chrysophanol against cognitive impairment in Wilson disease."METABOLIC BRAIN DISEASE.2023 Nov;:1-11

40. [IF=3.4] Si Li et al."Active ingredients of Erhuang Quzhi Granules for treating non-alcoholic fatty liver disease based on the NF-κB/NLRP3 pathway."FITOTERAPIA.2023 Dec;171:105704

39. [IF=2.8] Luo Jing et al."Chrysophanol improves memory impairment and cell injury by reducing the level of ferroptosis in Aβ25–35 treated rat and PC12 cells."3 Biotech.10.1007/s13205-023-03769-8

38. [IF=4.5] Guangtao Pan et al."Dachengqi decoction ameliorates sepsis-induced liver injury by inhibiting the TGF-β1/Smad3 pathways."Journal of Traditional and Complementary Medicine.10.1016/j.jtcme.2023.09.001

37. [IF=4.9] Zhang Min et al."Discovery and evaluation of active compounds from Xuanfei Baidu formula against COVID-19 via SARS-CoV-2 Mpro."Chinese Medicine.2023 Dec;18(1):1-14

36. [IF=3.1] Cuicui Liu et al."Identification and quantitative analysis of the chemical constituents of Gandouling tablets using ultra-high-performance liquid chromatography with quadrupole time-of-flight mass spectrometry."JOURNAL OF SEPARATION SCIENCE.2023 Jun;:2300

35. [IF=3.8] Yongle Yu et al."Novel anthraquinone photosensitizers: Synthesis, photoactivity, and 3D-QSAR studies."JOURNAL OF MOLECULAR STRUCTURE.2023 Nov;1292:136107

34. [IF=5.093] Zhang Meng et al."Chrysophanol exerts a protective effect against Aβ25-35-induced Alzheimer’s disease model through regulating the ROS/TXNIP/NLRP3 pathway."INFLAMMOPHARMACOLOGY.2023 Mar;:1-17

33. [IF=3.577] Liqing Zheng et al."The oxidative stress, mitochondrial pathway apoptosis, and the antagonistic effects of chrysophanol in SH-SY5Y cells via DTPP-induced photodynamic therapy."Photodiagnosis and Photodynamic Therapy.2022 Aug;:103062

32. [IF=3.205] Jiayun Chen et al."HRPIF data mining based on data-dependent/independent acquisition for Rhei Radix et Rhizoma metabolite screening in rats."J Chromatogr B. 2022 Feb;1190:123095

31. [IF=6.165] Yaofen Li et al.Study on the effects of deep eutectic solvents as a reaction media on the micromorphology of hydrogen-substituted graphyne and its adsorption and electrochemical properties.J Mol Liq. 2021 Nov;:118177

30. [IF=0.986] Ji-le Lan et al."Q-marker Prediction Analysis of Rhubarb in Fengyin Decoction Based on Fingerprint and Network Pharmacology:."Nat Prod Commun. 2021;16(8):

29. [IF=3] Qu  Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950

28. [IF=3.882] Kunpeng Yin et al."Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine."Langmuir. 2021;37(17):5321–5328

27. [IF=3.935] Li Xie et al."Development of an UHPLC-MS/MS method for comparative pharmacokinetics of nine anthraquinones in rats and application to dosage conversion between different Semen Cassiae forms."J Pharmaceut Biomed. 2019 Sep;174:696

26. [IF=4.36] Li Lin et al."Study on the protection of water extracts of Polygoni Multiflori Radix and Polygoni Multiflori Radix Praeparata against NAFLD and its mechanism."J Ethnopharmacol. 2020 Apr;252:112577

25. [IF=4.759] Yueping Jiang et al."Application of multifold characteristic ion filtering combined with statistical analysis for comprehensive profiling of chemical constituents in anti-renal interstitial fibrosis I decoction by ultra-high performance liquid chromatogra

24. [IF=5.645] Li-Xia Dai et al."Ultrasound-assisted extraction of five anthraquinones from Rheum palmatum water extract residues and the antimicrobial activities."Ind Crop Prod. 2021 Apr;162:113288

23. [IF=5.81] Zhihui Yin et al."Rhein Relieves Oxidative Stress in an Aβ1-42 Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis."Front Pharmacol. 2021; 12: 746711

22. [IF=2.406] Guo  Lei et al."Optimized extraction process and identification of antibacterial substances from Rhubarb against aquatic pathogenic Vibrio harveyi."3 Biotech. 2017 Dec;7(6):1-9

21. [IF=3.366] Wu  Xingqiang et al."A Novel Selective Accelerated Solvent Extraction for Effective Separation and Rapid Simultaneous Determination of Six Anthraquinones in Tartary Buckwheat and Its Products by UPLC–DAD."Food Anal Method. 2015 May;8(5):1124-1132

20.  Xie, Li, et al. "Development of an UHPLC-MS/MS method for comparative pharmacokinetics of nine anthraquinones in rats and application to dosage conversion between different Semen Cassiae forms." Journal of pharmaceutical and biomedical analysis 174 (2019):

19.  Guo, L., Guo, J. & Xu, F. Optimized extraction process and identification of antibacterial substances from Rhubarb against aquatic pathogenic Vibrio harveyi . 3 Biotech 7, 377 (2017). https:##doi.org/10.1007/s13205-017-1012-2

18.  張明明. 大黃道地產區核心種質構建及優良種質篩選研究[D].北京中醫藥大學,2020.

17.  李承浩,王萌,任曉亮.磺化杯6芳烴對4類中藥單體成分增溶作用及其機制研究[J].中國現代中藥,2020,22(12):2032-2038.

16.  蘭濟樂,阮葉萍,邱璐琦.基于BAS-GA-BP神經網絡結合熵權法多指標優化風引湯提取工藝[J].中國中藥雜志,2020,45(23):5686-5693.

15.  青,何前松,胡斐然,蔡友德,李宇鴻.大黃酚通過TLR4/NF-kB信號通路途徑調控小膠質細胞炎性反應[J].醫學信息,2020,33(19):51-54+58.

14.  陸杰,王婷婷,梁琨,安叡,王新宏,陳穎.UPLC-LTQ-Orbitrap-MS法分析大承氣湯化學成分[J].中成藥,2020,42(12):3275-3280.

13.  張亞洲,蔡友德,胡斐然,郭青,李宇鴻,何前松.大黃酚對腦缺血損傷模型大鼠小膠質細胞活化及炎癥因子表達的影響[J].中國藥房,2020,31(23):2858-2863.

12.  劉全德,唐仕榮,宋慧,王營,邢洪偉.蘆薈蒽醌類化合物的超聲提取及其抗氧化性研究[J].食品與機械,2011,27(05):68-71.

11.  郭允, 陳永超, 李曉花,等. 牛黃解毒片中6種指標成分的含量測定[J]. 沈陽藥科大學學報, 2016(6):454-458.

10.  陳侃, 王長謙, 范虞琪,等. 斑馬魚平臺研究七種中藥單體的降脂作用[J]. 生理學報, 2017, 069(001):55-60.

9.  楊強  蒲曉輝  李曉花. 一清膠囊中7種指標成分的測定[J]. 華西藥學雜志  2017(3).

8.  李曉花 郭允 李佳 袁琦 蒲曉輝 王高峰.RP-HPLC法同時測定三黃片中7種指標成分的含量[J].沈陽藥科大學學報 2016 33(08):637-642.

7.  魏艷婷  張靜宜  張華潭 等. HPLC法同時測定三黃滴丸中5種蒽醌類成分的含量[J]. 中國藥房  2015.

6.  黑小斌,李歡,李依民,王光輝,徐進,彭亮,鄧翀,顏永剛,郭順星,張崗.藥用大黃幼苗轉錄組高通量測序及蒽醌類生物合成基因篩選[J].中國藥學雜志,2019,54(07):526-535.

5.  李紅英  向極釬  龍瀾 等. HPLC法測定大黃藥材中5種游離蒽醌的含量[J]. 安徽農業科學  2013(12):5278-5279.

4.  李歡  黑小斌  李依民 等. HPLC法分析不同年限及不同部位掌葉大黃9種成分的積累特征[J]. 天然產物研究與開發  2019  031(006):923-931.

3.  李歡  黑小斌  李依民 等. HPLC分析不同年限藥用大黃不同部位中10種成分的積累特征[J]. 中草藥  2019  50(07):191-198.

2.  楊國靜  張珞琪  陳隨清 等. 不同商品規格決明子的質量分析[J]. 中國現代中藥  2018  v.20(08):963-967.

1.  賈麗華 黃剛 王東東 付曉.HPLC法測定不同廠家三黃片中大黃素與大黃酚的含量[J].兵團醫學 2016 47(01):51-53.

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