苦參堿

分析標準品,HPLC≥98%

Matrine

CAS號：519-02-8

分子式：C15H24N2O

分子量：248.36

MDL：MFCD00210527

產品介紹

Matrine (Matridin-15-one) 是一種在槐屬植物中發現的生物堿，可作為 kappa 阿片受體和 u-受體激動劑。Matrine 具有多種藥理作用，包括抗癌、抗氧化應激、抗炎和抗凋亡作用，可用于人類非小細胞肺癌、肝癌、甲狀腺乳頭狀癌和急性腎損傷 (AKI) 等疾病的研究。

熔點：77 ℃

沸點：396.7 ℃ at 760 mmHg

比旋光度：(C=1, EtOH)+33

外觀：針狀或棱狀結晶

溶解性：DMSO:≥50mg/mL(201.32mM)

H2O:20mg/mL(80.53mM;Needultrasonic)

儲存條件：2-8℃

注意：部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(60篇)

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58. [IF=4.9] Bo Yang et al."A liquid chromatography-tandem mass spectrometry method to determine total matrine residues in edible porcine tissues and its application in a tissue residue depletion study."MICROCHEMICAL JOURNAL.2024 Nov;:112139

57. [IF=5.3] Peijie Wang et al."Potential application of matrine microneedles for the treatment of atopic dermatitis in joint skin."INTERNATIONAL JOURNAL OF PHARMACEUTICS.2025 Jan;668:124992

56. [IF=2.8] Zhuoni Liu et al."Eutectic Solvents Based on Matrine and Fatty Acids as Solubility and Stability Enhancers of Curcumin."JOURNAL OF PHYSICAL CHEMISTRY B.2025;XXXX(XXX):XXX-XXX

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42. [IF=8.44] Zhang Ming et al."Matrine alleviates depressive-like behaviors via modulating microbiota–gut–brain axis in CUMS-induced mice."Journal of Translational Medicine.2023 Dec;21(1):1-18

41. [IF=4.462] Zheng Sun et al."Matrine can be absorbed and transmitted bidirectionally to defend against aphids (Hemiptera: Aphididae) on wheat and pepper."PEST MANAGEMENT SCIENCE.2023 Feb;:

40. [IF=2.13] Xinfeng Chang et al."Matrine inhibits hepatocellular carcinoma cell malignancy through the circ_0013290/miR-139-5p/MMP16 pathway."HISTOLOGY AND HISTOPATHOLOGY.2022 Dec 14;18574

39. [IF=4.966] Yang Li et al."Functional analysis of 3 genes in xenobiotic detoxification pathway of Bursaphelenchus xylophilus against matrine."PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY.2023 Feb;190:105334

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36. [IF=5.165] Juanning Ren et al."Qualitative and quantitative analysis of multi-components in Xing-Su-Ning Capsules for quality improvement."Arab J Chem. 2022 Jun;15:103825

35. [IF=2.1] Jikun Du et al."Matrine exerts anti?breast cancer activity by mediating apoptosis and protective autophagy via the AKT/mTOR pathway in MCF?7 cells."Mol Med Rep. 2020 Nov;22(5):3659-3666

34. [IF=2.447] Guanglei Wang et al."Matrine ameliorates the inflammatory response and lipid metabolism in vascular smooth muscle cells through the NF?κB pathway."Exp Ther Med. 2021 Nov;22(5):1-8

33. [IF=4.268] Qing Zhao et al."The water extract of Sophorae tonkinensis Radix et Rhizoma alleviates non-alcoholic fatty liver disease and its mechanism."Phytomedicine. 2020 Oct;77:153270

32. [IF=4.932] Sihao Zheng et al."Combination of matrine and tacrolimus alleviates acute rejection in murine heart transplantation by inhibiting DCs maturation through ROS/ERK/NF-κB pathway."Int Immunopharmacol. 2021 Dec;101:108218

31. [IF=1.448] Wang  Xie et al."Matrine inhibits the proliferation and migration of lung cancer cells through regulation of the protein kinase B/glycogen synthase kinase?3β signaling pathways."Exp Ther Med. 2018 Aug;16(2):723-729

30. [IF=3.943] Kangfeng Jiang et al."Matrine alleviates Staphylococcus aureus lipoteichoic acid-induced endometritis via suppression of TLR2-mediated NF-κB activation."Int Immunopharmacol. 2019 May;70:201

29. [IF=4.411] Jifeng Gu et al."Application of High-Performance Liquid Chromatography Coupled with Linear Ion Trap Quadrupole Orbitrap Mass Spectrometry for Qualitative and Quantitative Assessment of Shejin-Liyan Granule Supplements."Molecules. 2018 Apr;23(4):884

28. [IF=5.81] Shang  Xiaofei et al."The Anti-diarrheal Activity of the Non-toxic Dihuang Powder in Mice."Front Pharmacol. 2018 Sep;0:1037

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24.  Diao, Jian, et al. "Bioinformatics analysis of structure and function in the MRP gene family and its expression in response to various drugs in Bursaphelenchus xylophilus." Journal of Forestry Research 32.2 (2021): 779-787.https:##doi.org/10.1007/s11676-01

23.  Jiang, Kangfeng, et al. "Matrine alleviates Staphylococcus aureus lipoteichoic acid-induced endometritis via suppression of TLR2-mediated NF-κB activation." International immunopharmacology 70 (2019): 201-207.https:##doi.org/10.1016/j.intimp.2019.02.033

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