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GsMTx4 

Selective blocker of mechanosensitive ion channels

壓力敏感性離子通道選擇性阻斷劑

GsMTx4 (GsMTx-4, M-theraphotoxin-Gr1a) has been isolated from the venom of the spider Grammostola rosea. This cationic hydrophobic polypeptide blocks selectively the gating of cation selective channels and mechanosensitive ion channels such as TRPC1 or TRPC6, without having any effect on whole-cell voltage-sensitive currents. This toxin acts by perturbing the interface between the channel and the lipid bilayer without necessarily being in physical contact with the channel. GsMTx4 also demonstrated to active TRPA1 channel at 1µM concentration and to inhibit Piezo1 currents.

技術資料

氨基酸序列：

Gly-Cys²-Leu-Glu-Phe-Trp-Trp-Lys-Cys⁹-Asn-Pro-Asn-Asp-Asp-Lys-Cys¹⁶-Cys¹⁷-Arg-Pro-Lys-Leu-Lys-Cys²³-Ser-Lys-Leu-Phe-Lys-Leu-Cys³⁰-Asn-Phe-Ser-Phe-NH₂ 

二硫鍵：Cys²-Cys¹⁷, Cys⁹-Cys²³ and Cys¹⁶-Cys³⁰ 

長度 (aa)：34

分子式：C₁₈₅H₂₇₃N₄₉O₄₅S₆ 

分子量：4095.2 Da

外觀：White lyophilized solid

可溶性：water and saline buffer 

CAS 號：not available 

來源： Synthetic 

純度： > 97 %

產品信息