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Obtustatin 

Inhibitor of the binding of α₁β₁ integrin to collagen IV

抑制α₁β₁整合素與膠原蛋白IV結合

Obtustatin is a 41 amino acid disintegrin peptide isolated from the venom of the Vipera lebetina obtusa. It is a potent (IC₅₀ = 2 nM) and selective inhibitor of the binding of α₁β₁ integrin to collagen IV. Contrary to other known disintegrins, it does not contain the classical RGD sequence.  does not show inhibitory activity toward other integrins, including α₂β₁, α_IIbβ₃, α_vβ₃, α₄β₁, α₅β₁, α₆β₁, and α₉β₁, α₄β₇ integrins.  potently inhibits angiogenesis in chicken and in mouse model and reduces tumor development by half.

技術資料

氨基酸序列：Cys¹-Thr-Thr-Gly-Pro-Cys⁶-Cys⁷-Arg-Gln-Cys¹⁰-Lys-Leu-Lys-Pro-Ala-Gly-Thr-Thr-Cys¹⁹-Trp-Lys-Thr-Ser-Leu-Thr-Ser-His-Tyr-Cys²⁹-Thr-Gly-Lys-Ser-Cys³⁴-Asp-Cys³⁶-Pro-Leu-Tyr-Pro-Gly-OH 

二硫鍵： Cys¹-Cys¹⁰, Cys⁶-Cys²⁹, Cys⁷-Cys³⁴ and Cys¹⁹-Cys³⁶ 

長度（aa）：41 

分子式： C₁₈₄H₂₈₄N₅₂O₅₇S₈ 

分子量：4393.13 Da 

外觀：White lyophilized solid 

可溶性：aqueous buffer 

CAS 號： not available 

來源： Synthetic 

純度： > 97 %

產品信息