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 Psalmotoxin 1 /PcTx1 

ASIC1a selective blocker(酸敏感通道ASIC1a選擇性阻斷劑)

Psalmotoxin-1 (PcTx1, Pi-theraphotoxin-Pc1a) has been isolated from the venom of the Spider Psalmopoeus cambridgei (Trinidad chevron tarantula). PcTx1 is known to block potently (IC₅₀ = 1 nM) and selectively the H+-gated sodium channel ASIC1a (acid-sensitive ion channel 1a). The blockage is rapid and reversible.  PcTx1 can distinguish between the two ASIC1 splice variants ASIC1a and ASIC1b. PcTx1  loses its capacity to block ASIC1a as soon as this subunit is associated with another member of the family (ASIC2a or ASIC3). PcTx1 demonstrates an analgesic effect in acute and neuropathic pain models.

PcTx1技術資料

氨基酸序列：Glu-Asp-Cys³-Ile-Pro-Lys-Trp-Lys-Gly-Cys¹⁰-Val-Asn-Arg-His-Gly-Asp-Cys¹⁷-Cys¹⁸-Glu-Gly-Leu-Glu-Cys²³-Trp-Lys-Arg-Arg-Arg-Ser-Phe-Glu-Val-Cys³³-Val-Pro-Lys-Thr-Pro-Lys-Thr

二硫鍵：Cys³-Cys¹⁸, Cys¹⁰-Cys²³ and Cys¹⁷-Cys³³ 

長度 (aa)： 40

分子式： C₂₀₀H₃₁₂N₆₂O₅₇S ₆ 

分子量： 4690.82 Da

外觀：White lyophilized solid 

可溶性： water and saline buffer

CAS 號：not available

來源：Synthetic 

純度： > 98%

產品信息