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英文名稱	Estrogen Receptor alpha
中文名稱	雌激素受體α抗體
別名	Estradiol receptor; Estrogen receptor alpha; Estradiol Receptor-alpha; Estrogen Receptor 1; Atherosclerosis, susceptibility to, included; DKFZp686N23123; ER Alpha; ER; ER-alpha; ERalpha; ER[a]; Era; ESR; ESR1; ESR1_HUMAN; ESR2; ESRA; Estr; Estrogen receptor 1 (alpha); Estrogen resistance, included; HDL cholesterol, augmented response of, to hormone replacement, included; Myocardial infarction, susceptibility to, included; NR3A1; Nuclear receptor subfamily 3 group A member 1; OTTHUMP00000017718; OTTHUMP00000017719; RNESTROR.
	Specific References (1) \| bs-0122R has been referenced in 1 publications. [IF=1.85] Zhou, Dawei, et al. "Estrogen receptor alpha is essential for the proliferation of prostatic smooth muscle cells stimulated by 17???\estradiol and insulin?\like growth factor 1."ll biochemistry and function 29.2 (2011): 120-125.... WB ; Mouse. PubMed:21287577
規格價格	50ul/780元 100ul/1380元 200ul/2200元大包裝/詢價
說明書	50ul 100ul 200ul
研究領域	腫瘤免疫學生長因子和激素
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, Rat, Dog, Cow, Rabbit,
產品應用	WB=1:500-2000 ELISA=1:500-1000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	67kDa
細胞定位	細胞核
性狀	Lyophilized or Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from the middle of human Estrogen Receptor alpha:331-360/595
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
產品介紹	background: Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER Alpha and ER Beta. ER Alpha and ER Beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors. Function: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Subunit: Interacts with SLC30A9 (By similarity). Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2, PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with KDM. Interacts with SMARD1. Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1. Interaction with MUC1 is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated transcription. Interacts with DNTTIP2, FAM120B and UIMC1. Interacts with isoform 4 of TXNRD1. Interacts with MLL2. Interacts with ATAD2 and this interaction is enhanced by estradiol. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity. Glycosylated; contains N-acetylglucosamine, probably O-linked. Similarity: Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. SWISS: P06211 Gene ID: 2099 Database links: Entrez Gene: 407238 Cow Entrez Gene: 403640 Dog Entrez Gene: 2099 Human Entrez Gene: 13982 Mouse Entrez Gene: 24890 Rat Omim: 133430 Human SwissProt: P49884 Cow SwissProt: P03372 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 類固醇受體（Steroid Receptors）雌激素受體ER-α（Estrogen Receptor-α, ERα）是一類位于細胞表面或細胞內的特異性蛋白質。某些特異的雌激素、雌激素類似物、衍生物、拮抗劑或阻斷劑與它結合后可引發或阻斷受體蛋白質的轉化作用。并將雌激素-受體復合物從細胞質再定位進入細胞核以啟動蛋白質的生物合成。
產品圖片	Sample:MCF-7 Cell Lysate at 30ug; Primary: Anti-Estrogen Receptor alpha (bs-0122R) at 1:300; Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000; Predicted band size: 67 kD Observed band size: 67 kD Sample: MCF-7 Cell Lysate at 30ug; DU145 Cell Lysate at 30 ug; Primary: Anti-Estrogen Receptor alpha (bs-0122R) at 1:300; Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000; Predicted band size: 67 kD Observed band size: 67 kD Sample: A549(Human) Cell Lysate at 30 ug Primary: Anti-Estrogen Receptor alpha (bs-0122R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 67 kD Observed band size: 67 kD Sample: MCF-7 Cell (Human) Lysate at 30 ug Primary: Anti- Estrogen Receptor alpha (bs-0122R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 67kD Observed band size: 65kD