中文摘要：

妊娠會引發機體免疫系統發生深刻變化。然而，妊娠狀態下呼吸道針對流感感染的免疫適應性變化，及其對疾病嚴重程度的影響，目前仍尚不明確。

本研究利用妊娠中期臨床前動物模型，揭示了一種鼻腔局部宿主抗甲型流感病毒（IAV）防御增強的分子機制：該機制可抑制病毒復制，并減弱肺內免疫應答反應強度。因此，妊娠小鼠在感染甲型流感病毒后，肺部病理損傷減輕，氣道功能得以維持。

這種對病毒復制的早期抑制不依賴 I 型干擾素（IFN），而是由鼻腔內白介素 - 17 陽性（IL-17?）γδ T 細胞驅動 抗菌肽（AMPs） 表達上調所介導。妊娠期上呼吸道這套抵御甲型流感病毒感染的宿主防御通路，能夠限制病毒早期侵染、阻止病毒向肺部擴散，進而維持母體健康狀態。

英文摘要：

Pregnancy is associated with profound changes in immunity. However, pregnancy-related respiratory immune adaptations in response to influenza infection and their impact on disease severity remain unclear. Here, we describe, in a preclinical model of mid-gestation pregnancy, a mechanism of enhanced host defense against influenza A virus (IAV) localized to the nasal cavity that limits viral replication and reduces the magnitude of intrapulmonary immune responses. Consequently, the pregnant mice show reduced pulmonary pathology and preserved airway function after IAV infection. The early restriction of viral replication is independent of type I interferon (IFN) but dependent on increased antimicrobial peptides (AMPs) driven by interleukin-17+ (IL-17+) γδ+ T cells within the nasal passages. This pathway of host defense against IAV infection in the upper airways during pregnancy restricts early viral infection and prevents virus dissemination into the lung supporting maternal fitness.

論文信息：

論文題目：Pregnancy enhances antiviral immunity independent of type I IFN but dependent on IL-17–producing γδ+ T cells in the nasal mucosa

期刊名稱：Science Advances

時間期卷：Vol 10, Issue 39(2024)

在線時間：2024年9月27日

DOI: 10.1126/sciadv.ado7087

產品信息：

貨號：CP-005-005

規格：5ml+5ml

品牌：Liposoma

產地：荷蘭

名稱：Clodronate Liposomes&Control Liposomes

辦事處：靶點科技

Clodronate Liposomes氯膦酸鹽脂質體在甲型流感病毒感染妊娠小鼠模型種清除肺部巨噬細胞。荷蘭Liposoma巨噬細胞清除劑ClodronateLiposomes見刊于Science Advances：妊娠可增強抗病毒免疫，該過程不依賴 I 型干擾素，而依賴鼻黏膜中分泌 IL-17 的 γδ? T 細胞

Liposoma巨噬細胞清除劑Clodronate Liposomes氯膦酸二鈉脂質體清除巨噬細胞的材料和方法：

AM depletion

巨噬細胞清除材料和方法文獻截圖：