【26年3月文獻戰報】博奧森高分文獻精彩呈現

時間：2026-5-12 閱讀：294

截至目前，引用Bioss產品發表的文獻共39,151篇，總影響因子200,214.07分，發表在Nature, Science, Cell, Cancer Cell以及Immunity等頂級期刊的文獻共140篇，合作單位覆蓋了清華、北大、復旦、華盛頓大學、麻省理工學院、東京大學以及紐約大學等上百所國際研究機構。
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本文主要分享11篇IF≥19的文獻，它們引用了Bioss產品，分別發表在Cell、Nature Biotechnology、Nature Photonics、Nature Methods、Nature Immunology、Advanced Materials、Advanced Fiber Materials、Cell Stem Cell、Bioactive Materials、Advanced Functional Materials期刊上，讓我們一起學習吧。

Cell [IF=42.5]

文獻引用產品：

bs-4630R | phospho-ROCK1 Rabbit pAb | mlF

作者單位：四川大學華西第二醫院

摘要：Liver fibrosis is a prominent pathological process contributing to death from hepatic diseases, including metabolic dysfunction-associated steatohepatitis (MASH). There is limited treatment for liver fibrosis. Here, we find that upregulation of Rho-associated coiled-coil containing kinase 2 (ROCK2) in liver endothelial cells (ECs) and perivascular hepatic stellate cells (HSCs) causes vascular niche dysfunction and triggers pro-fibrotic angiocrine signaling. Based on the vascular druggable target ROCK2, we developed its selective inhibitor showing anti-fibrotic potency in preclinical models and human patients. The ROCK2-selective inhibitor TDI01 restored vascular phenotype and alleviated fibrosis in rodent and minipig MASH models. A phase 1 clinical trial (ChiCTR2200058868) of TDI01 demonstrated its favorable pharmacokinetics and safety in humans. An extended clinical trial (ChiCTR2400082056) showed a trend toward reducing liver fibrosis in five of six patients after TDI01 treatment. Thus, we discover vascular ROCK2 as a pro-fibrotic target, and development of an inhibitor selectively targeting angiocrine ROCK2 may provide a treatment of liver fibrosis in human patients.

Nature Biotechnology [IF=41.7]

文獻引用產品：

D10200 | ProClin 300 | Other

作者單位：復旦大學

摘要：Dual-objective 4Pi single-molecule localization microscopy (4Pi-SMLM) offers isotropic nanoscale resolution; however, its broader adoption is limited by instrumental complexity and stringent alignment requirements. Here we introduce mirror-enhanced 4Pi-SMLM (me4Pi-SMLM), a single-objective configuration that uses mirror-based retroreflection of the illumination beam to generate phase-tunable interference fringes. This design improves the axial resolution of astigmatism-based methods by approximately fivefold, delivering performance comparable to conventional 4Pi-SMLM while greatly reducing system complexity and maintenance. me4Pi-SMLM achieves near-isotropic localization precision of 2–3?nm in biological samples, enabling clear and unambiguous visualization of diverse ultrastructural features. Furthermore, it achieves sub-15?nm isotropic resolution in brain slices and facilitates high-fidelity two-colour imaging, nanoscale whole-cell reconstruction and live-cell imaging. me4Pi-SMLM can be seamlessly integrated into existing 3D-SMLM systems, enhancing performance with minimal cost and effort.

Nature Photonics [IF=32.9]

文獻引用產品：

C-0005 | Normal Goat Serum | Other

作者單位：華中科技大學

摘要：Despite its proven value for biomedical research, super-resolution structured illumination microscopy still faces challenges in both fidelity of image reconstruction and imaging speed. Substantial background interference introduces artefacts and degrades resolution, while computationally intensive image reconstruction and illumination pattern switching limit imaging throughput. Here we present digital array modulation microscopy (DaMo), which combines digital array modulation with a single-spectrum reconstruction algorithm. Gaussian illumination modulation combined with digital detection modulation enables heterodyne detection with a 100% contrast. Therefore, DaMo achieves high-fidelity reconstruction (Pearson correlation coefficient 0.99?±?0.01) under substantial background interference, with a 102× faster reconstruction speed than state-of-the-art super-resolution structured illumination microscopy processing. DaMo offers an axial resolution of 300?nm and a lateral resolution of 100?nm while achieving a 1,284-fold improvement in the signal-to-background ratio in whole-cell three-dimensional imaging. DaMo operates without additional modulators or extra image enhancement, providing artefact-free precision with a streamlined workflow. We demonstrate the versatility of DaMo via quantitative live-cell imaging of actin dynamics, tracking of cascaded filopodia fusion events, multicolour whole-smear imaging for cell cycle profiling, and tissue pathology assessment of intestinal epithelial injury in mitochondria. DaMo paves the way for large-scale, background-suppressed super-resolution imaging across diverse biological systems.

Methods [IF=32.1]

文獻引用產品：

bs-11347R | GRID2IP Rabbit pAb | IF

bs-12140R | DLGAP4 Rabbit pAb | IF

作者單位：美國伊利諾伊大學

摘要：Understanding neuronal connectivity at single-cell resolution remains a fundamental challenge in neuroscience, with current methods particularly limited in mapping long-distance circuits and preserving cell type information. Here we present Connectome-seq, a high-throughput method that combines engineered synaptic proteins, RNA barcoding and parallel single-nucleus and single-synaptosome sequencing to map neuronal connectivity at single-synapse resolution. This adeno-associated virus-based approach enables simultaneous capture of both synaptic connections and molecular identities of connected neurons. We validated this approach in the mouse pontocerebellar circuit, identifying both established and potentially uncharacterized synaptic connections. Through integrated analysis of connectivity and gene expression, we identified molecular markers enriched in connected neurons, suggesting potential molecular determinants of circuit-specific connectivity. By enabling systematic mapping of neuronal connectivity across brain regions with single-cell precision and gene expression information, Connectome-seq provides a scalable platform for comprehensive circuit analysis across different experimental conditions and biological states.

Nature Immunology [IF=27.6]

文獻引用產品：

bs-3195R-PerCP | phospho-IRF3 Rabbit pAb, PerCP conjugated | FC

bs-3196R-BF350 | phospho-IRF7 (Ser471 + Ser472) Rabbit pAb, BF350 conjugated | FC

作者單位：美國埃默里大學

摘要：Immune interventions toward an HIV cure have focused on rejuvenating adaptive immune responses. Herein we provide a framework that features epigenetic programming of myeloid and CD4⁺ T cells as a major mechanism that promotes decay of the HIV reservoir. Coordinate regulation of gene expression and chromatin accessibility of pathways of innate antiviral immunity was associated with decay of cell-associated viral DNA (CA-vDNA) following analytical treatment interruption in simian immunodeficiency virus-infected rhesus macaques (RMs) treated with anti-IL-10 and anti-PD-1. TGF-β/SMAD signaling in a subset of combo-treated CA-vDNA^hi RMs, suppressed this antiviral activity through histone deacetylases, reducing chromatin accessibility of interferon regulatory factors (IRFs) and STATs. Addition of HDAC inhibitors in vitro restored antiviral response in the presence of TGF-β. Induction of IL-6 in CA-vDNA^lo RMs amplified the antiviral network through IRF9. We identified an overlapping molecular cascade in HIV elite controllers, who maintain small HIV reservoirs without antiviral treatment. These data provide insights into strategies for HIV cure interventions.

Advanced Materials [IF=26.8]

文獻引用產品：

bs-8687R | P53 Rabbit pAb | FC, IF

作者單位：吉林大學口腔醫學院

摘要：Periodontitis is driven by a self-reinforcing cycle of persistent inflammation and cellular senescence, further exacerbated by pathogenic microbial colonization. To address this challenge, inspired by the “fortress effect", we report an allicin-based nanoplatform of biolubrication (PPCG) that establishes a physical and biological protective barrier for precise modulation of the periodontal microenvironment. PPCG integrates hydration-lubricating diblock copolymer P(DMA-bMPC) (PDMPC) with bioactive allicin. The lubricating PDMPC barrier may suppress pathogenic microbial adhesion and biofilm formation, constituting an “outer fortress wall" against bacterial invasion. Concurrently, sustained release of allicin could regulate bone marrow mesenchymal stem cells (BMMSCs) and mitigate inflammatory responses. It could preserve stemness and multipotent differentiation potential, thereby forming an “inner defensive citadel" that promotes soft and hard tissue regeneration. This dual protective barrier can markedly attenuate periodontal tissue senescence and inflammatory and prevent alveolar bone loss in mice periodontitis model. Furthermore, PPCG could rebalance the oral microbiota and maintain ecological homeostasis. Therapeutic efficacy is also corroborated using an artificial intelligence-assisted detection system based on the YOLO v8 deep learning model. Collectively, this study presents a therapeutic intervention strategy for periodontitis, offering a scalable and translational approach for treating inflammation and senescence.

Advanced Fiber Materials [IF=21.3]

文獻引用產品：

bs-0812R | IL-1 Beta Rabbit pAb | IHC

bsm-55603R | TNF-alpha Recombinant Rabbit mAb | IHC

bsm-10807M | Human IL-6 Mouse mAb | IHC

bs-0698R | IL-10 Rabbit pAb | Other

bs-1313R | VEGFA Rabbit pAb | IHC

bs-1035R | CD86 Rabbit pAb | IHC

bsm-55604R | MRC1 | CD206 Recombinant Rabbit mAb | IHC

作者單位：江南大學

摘要：Excessive exudate accumulation and chronic inflammation are major barriers to diabetic wound repair, leading to infection risk and impaired tissue regeneration. Conventional dressings lack elasticity and intimate skin conformability, often adhering to fragile tissue and causing secondary trauma. Herein, we developed an ultra-conformable Janus dressing composed of a gentamicin sulfate (GS)-loaded styrene–ethylene–butylene–styrene (SEBS) immune-modulating layer and a PEO–PPO–PEO triblock copolymer (F127)/curcumin (Cur)-loaded thermoplastic polyurethane (TPU) pH-visualizing layer. The asymmetric design integrates differences in surface wettability and fiber porosity between the two layers and enables unidirectional and anti-gravity transport of wound exudate from the SEBS/GS side to the TPU/F127/Cur side, effectively preventing fluid reflux and reducing infection risk. The soft and elastic polymeric matrix ensures intimate wound conformity and mechanical protection, while facilitating angiogenesis and collagen deposition. Furthermore, the pH-responsive dressing not only absorbs inflammatory exudates, but also provides visual, dynamic monitoring of the healing process through pH-dependent color changes. In vitro assays and histological analyses demonstrated that GS-mediated immunomodulation via inflammation suppression and microenvironment improvement markedly accelerated wound closure in diabetic models within 12days. This multifunctional dressing offers a promising pathway toward next-generation, intelligent, and patient-friendly therapies for chronic diabetic wounds.

Cell Stem Cell [IF=20.4]

文獻引用產品：

C2055 | 4% PFA, RNase free | Other

作者單位：浙江大學醫學院附屬第一醫院

摘要：Understanding biological processes requires spatiotemporal mapping of proliferative and transcriptional dynamics. Current spatial transcriptomics methods capture only protein-coding transcripts and static snapshots, obscuring non-coding RNAs (ncRNAs) and dynamic events. We developed SPTEdU-seq, integrating spatial total transcriptomics with 5-ethynyl-2′-deoxyuridine tracking to co-profile gene expression and proliferation dynamics. SPTEdU-seq demonstrates ultrahigh sensitivity for coding and non-coding transcripts and for splicing isoforms, with single-molecule probe design eliminating optical imaging. Applied to developing and adult mouse brains, it revealed spatial lncRNA patterns, reconstructed developmental trajectories, and enabled spatiotemporal lineage tracing. In murine ischemic stroke, it mapped regeneration dynamics and identified an Igfbp5⁺ astrocyte subtype within a pro-repair niche. In mouse and human renal tumors, it uncovered tumor-associated splicing and detected diagnostic 3p loss. By profiling newborn and resident cells in intact microenvironments, it unveiled previously inaccessible interaction networks. SPTEdU-seq thus establishes a powerful framework for investigating cell fate dynamics in regeneration, development, and cancer.

Bioactive Materials [IF=20.3]

文獻引用產品：

bs-0782R | IL-6 Rabbit pAb | IHC

作者單位：中南大學湘雅醫院

摘要：Traumatic brain injury (TBI) causes acute neuronal and vascular damage accompanied by intense neuroinflammation, yet current surgical and pharmacological interventions yield limited long-term benefits. Embryonic stem cell-derived small extracellular vesicles (ESC-sEV) carry potent pro-repair signals but suffer from poor brain targeting and rapid clearance in the acute inflammatory window. To address these critical limitations, we engineered an injectable ESC-sEV–glycyrrhizic acid (GA) co-assembled hydrogel (EG-gel) in which sEVs act as a functional gel factor interpenetrating GA nanoscaffolds. GA molecules were self-assembled into nanoscaffolds via hydrogen bonding, with polar head groups coordinating to sEV membranes while hydrophobic cores insert into lipid bilayers, yielding a robust, hierarchical matrix. EG-gel exhibited brain-compatible mechanical properties, rapid self-healing, shear-thinning injectability, and strong tissue adhesion, which collectively enhance local sEV accumulation at the lesion site. In a mouse TBI model, the EG-gel showed superior neuroprotective effects and functional recovery outcomes compared with the GA-gel. Transcriptomics combined with experimental validation confirmed a spatiotemporal synergistic mechanism: GA mediated early inflammatory suppression and immune microenvironment stabilization, while co-assembled sEVs drove angiogenesis and neuronal repair. Therefore, the EG-gel played a synergistic role in establishing a sequential “first anti-inflammatory, then vaso-neural regeneration" microenvironment, thereby promoting neuroprotection after TBI. This work highlights the EG-gel as an up-and-coming candidate for translational therapy in TBI.

Bioactive Materials [IF=20.3]

文獻引用產品：

bs-0162R | NOS2/iNOS Rabbit pAb | IF

bs-23837R | Arginase 1 Rabbit pAb | IF

bs-10423R | Collagen I Rabbit pAb | IF

作者單位：總醫院第四醫學中心

摘要：Persistent hyperglycemia-induced mitochondrial oxidative stress causes mtDNA leakage, activating the STING signaling pathway in macrophages and eliciting sustained pro-inflammatory cytokine secretion, resulting in wound healing stagnation throughout the inflammatory phase. In this study, we developed a glucose/ROS-responsive hydrogel dressing (SG) employing dynamic crosslinking via boronate ester between chlorogenic acid (CGA)-conjugated gelatin and sodium alginate functionalized with 3-aminophenylboronic acid. Furthermore, the engineered macrophage-targeting phosphatidylserine (PS)-incorporated liposomes (HPSL), designed for the precise delivery of the STING inhibitor H151, were incorporated into the hydrogel (HPSL@SG). This hydrogel exhibits superior injectability, stretchability, self-healing properties, and adaptation to the irregular shapes of skin wounds. Upon injection into a diabetic wound, the as-prepared hydrogel disintegrated in response to elevated glucose and ROS, facilitating the on-demand release of CGA and HPSL. The CGA can directly scavenge ROS to alleviate oxidative stress, achieving a 79.9% reduction in superoxide anion levels; the HPSL specifically targets macrophages to prevent disturbance of immunologic homeostasis due to off-target effects. This process facilitates macrophage polarization towards an anti-inflammatory phenotype by inhibiting the STING signaling pathway, thereby suppressing the release of pro-inflammatory cytokines TNF-α and IL-6 and promoting the release of IL-10. The HPSL@SG hydrogel collectively enhances angiogenesis, evidenced by a 6.6-fold increase in CD31 levels and a 7.3-fold increase in VEGF levels, while also facilitating collagen deposition, with collagen content escalating from 32.6% to 69.3%. This procedure culminates in an 89.7% recovery within 10 days and nearly complete wound healing within 14 days, indicating its potential for clinical application in diabetic wound healing.

Advanced Functional

Materials [IF=19]

文獻引用產品：

bsm-52436R | Calreticulin Recombinant Rabbit mAb | WB, IF, IHC

bs-20633R | HMGB1 Rabbit pAb | WB, IF, IHC

bs-10900R | GAPDH Rabbit pAb, Loading Control | WB

作者單位：海南大學

摘要：Reactive oxygen species (ROS)-based therapies are promising for tumor ablation, but their efficacy is limited by hypoxic microenvironments and poor intratumoral penetration. This study presents a photo/sono/magneto-responsive ternary heteronanocrystal, BPNS/PCN-224/Fe₃O₄@PVP (BPF), incorporating an S-scheme heterojunction and Fe-based nanozyme catalysis. The S-scheme heterojunction between piezoelectric black phosphorus nanosheets (BPNS) and photosensitizing PCN-224 enhances ROS generation for synergistic photodynamic therapy (PDT) and ultrasound-piezocatalytic therapy (UPCT). Superparamagnetic Fe₃O₄ nanoparticles provide peroxidase- and catalase-like activities, further increasing oxidative stress and reinforcing PDT, UPCT, and chemodynamic therapy. This robust ROS production induces immunogenic cell death, activates immune memory, and elicits systemic antitumor responses. Under ultrasound and magnetic driving, BPF is enriched and actively transported into deep tumor regions, improving intratumoral distribution. The integrated platform achieves efficient ROS-amplified tumor cell killing, along with near-infrared fluorescence and T₂-weighted MRI for real-time treatment guidance. This multifunctional S-scheme heteronanocrystal offers a promising strategy for penetrative, ROS-amplified tumor ablation, and enhancing systemic antitumor immune responses.

北京博奧森生物技術有限公司

北京博奧森生物技術有限公司

【26年3月文獻戰報】博奧森高分文獻精彩呈現

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