巨哥科技從事精準(zhǔn)測(cè)溫?zé)嵯駜x研發(fā)十余年,助力各領(lǐng)域科研人員從事前沿科學(xué)研究,以下列舉生命科學(xué)領(lǐng)域細(xì)胞靶向研究的部分論文。
1. A Feasibility Study of Applying Thermal Imaging to Assist Quality Assurance of High-Dose Rate Brachytherapy,2017年9月發(fā)表于Cancer Translational Medicine
該研究探索了熱成像的一種新應(yīng)用,即可視化/定位HDR源,使用溫度信息測(cè)量放射性,實(shí)現(xiàn)在進(jìn)行高劑量率(HDR)近距離放射治療時(shí)可保證輻射安全和質(zhì)量。研究使用巨哥科技紅外熱像儀觀察由聚偏二氟乙烯(PVDF)制成的HDR源,通過(guò)HDR震源強(qiáng)度與加熱效應(yīng)之間的關(guān)系,建立QA標(biāo)準(zhǔn):(MAG62 from Magnity Electronics; thermal sensitivity 0.04K)

2. A Near Infrared-Modulated Thermosensitive Hydrogel for Stabilization of Indocyanine Green and Combinatorial Anticancer Phototherapy,2019年1月發(fā)表于Biomaterials Science
該研究利用超分子交聯(lián)共軛聚合物成功地合成了一種可注射的近紅外調(diào)制水凝膠平臺(tái),可以提高光療劑ICG的穩(wěn)定性,以光熱方式響應(yīng)溫度變化,并通過(guò)可逆凝膠-溶膠轉(zhuǎn)移通過(guò)近紅外控制ICG的釋放,有效殺傷癌細(xì)胞,并可在低劑量NIR照射下解決大多數(shù)4T1腫瘤而不復(fù)發(fā)。研究使用巨哥科技紅外熱像儀檢測(cè)小鼠在光療期間的腫瘤溫度變化:The real-time thermal images in vitro and in vivo were recorded with an infrared thermal camera (MAG30, Shanghai Magnity Electronics Technology Co., Ltd, China).

3. A simple, universal and multifunctional template agent for personalized treatment of bone tumors,2022年發(fā)表于Bioactive Materials第12期
該研究設(shè)計(jì)了一種通用的骨腫瘤治療模板載體,同時(shí)滿(mǎn)足骨靶向、腫瘤殺傷、破骨細(xì)胞抑制和腫瘤成像的需要。該模板由聚多巴胺(PDA)核心和多功能表面組成,阿侖膦酸鈉(ALN)被移植以實(shí)現(xiàn)其一般骨靶向功能。PDA核心可攜帶多種化療藥物,而豐富的ALN基團(tuán)可攜帶多種具有成像功能的金屬離子,可以針對(duì)不同的骨腫瘤患者設(shè)計(jì)更加個(gè)性化的治療方案。研究使用巨哥科技紅外熱像儀檢測(cè)不同濃度的PDA或PDA-ALN在激光照射下的溫度變化:Different concentration gradients of PDA or PDA-ALN were added in a 1 cm2 cuvette and irradiated with an 808 nm NIR laser at 3.6 W/cm2 for 10 min. The thermal infrared camera (Magnity Electronics, China) was used to monitor the temperature changes of PDA or PDA-ALN.

4. Biodegradable Poly(γ-glutamic acid)@glucose oxidase@carbon dot nanoparticles for simultaneous multimodal imaging and synergetic cancer therapy,2020年發(fā)表于Biomaterials,ELSEVIER
該研究開(kāi)發(fā)了一種新型納米材料,通過(guò)饑餓療法/光動(dòng)力療法(PDT)/光熱療法(PTT)和檢查點(diǎn)阻斷免疫療法的聯(lián)合作用來(lái)改善腫瘤治療,顯著提高治療效率,并且系統(tǒng)的抗腫瘤免疫反應(yīng)也將消除未照射的腫瘤。研究使用巨哥科技紅外熱像儀監(jiān)測(cè)照射過(guò)程中腫瘤部位的溫度變化:Infrared thermal images were recorded with a PTT monitoring system MAG33 (Shanghai Magnity Electronics Co. Ltd).

5. Chemotherapeutic Nanoparticle-Based Liposomes Enhance the Effificiency of Mild Microwave Ablation in Hepatocellular Carcinoma Therapy,2020年2月發(fā)表于Frontiers in Pharmacology
肝細(xì)胞癌(HCC)是導(dǎo)致癌癥死亡的第三大原因,微波消融(MWA)是一種微創(chuàng)療法,在治療肝癌方面取得了進(jìn)展,但肝癌復(fù)發(fā)仍然存在問(wèn)題。該研究利用開(kāi)發(fā)出的阿霉素脂質(zhì)體(DNPs)作為一種有效的納米平臺(tái),即使在輕度消融條件下也能提高M(jìn)WA效率,研究使用巨哥科技紅外熱像儀監(jiān)測(cè)小鼠進(jìn)行微波消融后的腫瘤溫度變化:Thermal imaging was recorded through an infrared thermal imaging camera (Magnity Electronics Co., China).

6. Deletion of Letmd1 leads to the disruption,2020年11月發(fā)表于bioRxiv
該研究表明,宮頸癌癌基因(LETMD1)通過(guò)調(diào)節(jié)線粒體結(jié)構(gòu)和功能,在控制棕色脂肪組織產(chǎn)熱和能量平衡方面起著至關(guān)重要的作用,為代謝疾病的臨床生物標(biāo)志物和癌基因治療靶點(diǎn)提供了新的見(jiàn)解。研究使用巨哥科技紅外熱像儀測(cè)量小鼠在缺少LETMD1后溫度變化情況:The infrared video was measured by an infrared thermal imager (Magnity Electronics Co.,Ltd, China).

7. Enhanced Plasmon-Induced Resonance Energy Transfer (PIRET)-mediated Photothermal and Photodynamic Therapy Guided by Photoacoustic and Magnetic Resonance Imaging,2019年發(fā)表于A C S Applied Materials and Interfaces
該研究開(kāi)發(fā)了一種新型的智能PIRET介導(dǎo)的納米平臺(tái),用于增強(qiáng)成像引導(dǎo)的光療法,有效殺傷癌細(xì)胞,抑制腫瘤生長(zhǎng)。研究使用巨哥科技紅外熱像儀記錄小鼠腫瘤部位在650激光照射下的紅外溫度圖像:The obtained infrared thermal images at tumor site exposuring to 650 laser light irradiation were recorded with a PTT monitoring system MAG33 (Shanghai Magnity Electronics Co. Ltd.).

8. Graphene loading water-soluble phthalocyanine for dual-modality photothermal/photodynamic therapy via a one-step method,2014年1月發(fā)表于Journal of Materials Chemistry B
該研究提出了一種新的、簡(jiǎn)便的一步法制備水溶性石墨烯的方法-酞菁(GR-Pc)將GR與親水性Pc、四磺酸四鈉鹽酞菁銅(TSCuPc)進(jìn)行超聲處理,制成雜化材料,為開(kāi)發(fā)有效的雙模態(tài)碳納米平臺(tái)進(jìn)行癌癥治療提供了一種簡(jiǎn)便的方法。研究使用巨哥科技紅外熱像儀每隔30秒收集不同溶液受到激光誘導(dǎo)產(chǎn)生的溫度變化。Light induced temperature change in the solutions were collected every 30 s by using a thermal camera (MAG30, Magnity Electronics, China).

9. Insufficient radiofrequency ablation promotes proliferation of residual hepatocellular carcinoma via autophagy,2018年2月發(fā)表于Cancer Letters
射頻消融(RFA)被認(rèn)為是肝細(xì)胞癌(HCC)的潛在治療方法。然而,RFA不足可促進(jìn)殘余腫瘤的快速進(jìn)展。該研究建立了皮下異種移植小鼠模型,通過(guò)超聲和熱像儀監(jiān)測(cè)射頻消融不足(IRFA)的位置和范圍,研究結(jié)果表明自噬在IRFA后的復(fù)發(fā)和增殖中起著重要作用,羥基氯喹(HCQ)可以抑制這些作用,可能是臨床上治療IRFA后肝癌局部復(fù)發(fā)的一種新方法。研究使用巨哥科技紅外熱像儀觀測(cè)射頻消融手術(shù)時(shí)腫瘤的溫度變化情況:Thermal imaging was recorded with a thermal camera (MAG30, Magnity Electronics Co. Ltd. Shanghai, China) when the tumors were exposed to RFA.

10. Liposome-based multifunctional nanoplatform as effective therapeutics for the treatment of retinoblastoma,2021年8月發(fā)表于Acta Pharmaceutica Sinica B
該研究通過(guò)模擬體內(nèi)納米載體的自然結(jié)構(gòu)和生物功能特性,獲得了一種新型納米顆粒ILP,在體內(nèi)外均能實(shí)現(xiàn)特異性腫瘤組織靶向和穿透,在熒光成像和光聲成像方面具有顯著優(yōu)勢(shì)。此外,ILP在實(shí)體瘤中的有效積累大大提高了腫瘤光熱治療的療效,為實(shí)現(xiàn)圖像引導(dǎo)腫瘤光熱治療提供了一種很有前景的策略。研究使用巨哥科技紅外熱像儀觀測(cè)在808 nm激光(1.5W)照射后的PBS、ICG和ILP溫度變化情況:the aqueous media were irradiated with NIR laser (808 nm) at a power intensity of 1.5 W/cm2 for 10 min and the changes of temperature were measured with an infrared thermal imaging camera (Magnity Electronics Co., Ltd., China).

11. Multifunctional Nanocomposites for Targeted, Photothermal, and Chemotherapy,2019年發(fā)表于Chemistry of Materials
該研究成功制備了具有增強(qiáng)靶向傳遞和化學(xué)光熱療法多功能的NCs,可顯著抑制腫瘤生長(zhǎng),對(duì)小鼠模型沒(méi)有明顯毒性。研究使用巨哥科技紅外熱像儀觀測(cè)激光照射過(guò)程中小鼠腫瘤位置的溫度變化情況:To monitor the temperature changes at the tumor site during irradiation, infrared thermal images were recorded with a PTT monitoring system MAG33 (Shanghai Magnity Electronics Co. Ltd).

12. Near-infrared light-mediated photodynamic/ photothermal therapy nanoplatform by the assembly of Fe3O4 carbon dots with graphitic black phosphorus quantum dots,2018年發(fā)表于International Journal of Nanomedicine
該研究使用簡(jiǎn)單、溫和、可靠的方法成功制備一種基于新型光敏劑/鉑劑(BPQDs)和靶向Fe3O4鎘劑的多功能治療劑,具有高度的生物相容性,并顯示出優(yōu)異的腫瘤抑制效果。研究使用巨哥科技紅外熱像儀監(jiān)測(cè)照射期間小鼠腫瘤部位的溫度變化:To monitor temperature changes at tumor sites during irradiation, IR thermal images were observed using a PTT monitoring system (MG33; Magnity Electronics, Shanghai, China).

13. NIR light-triggered gelling in situ of porous silicon nanoparticles/PEGDA hybrid hydrogels for localized combinatorial therapy of cancer cells,2018年10月發(fā)表于JOURNAL OF APPLIED POLYMER SCIENCE
該研究制備了具有較強(qiáng)的熒光性、良好的生物降解性、顯著的光熱效應(yīng)和高效的緩釋性多功能的PSiNPs/PEGDA納米復(fù)合水凝膠,在體外對(duì)癌細(xì)胞的存活、粘附和遷移提供顯著的局部抑制。研究使用巨哥科技紅外熱像儀觀測(cè)不同條件下PSINP/PEGDA水凝膠的ΔT–T曲線:the temperature elevation and thermal imaging of these samples was measured by thermal monitoring system MAG33 (Shanghai Magnity Electronics Co. Ltd.).

14. Preparation of injectable hydrogel with near-infrared light response and photo-controlled drug release,2020年發(fā)表于Bioresources and Bioprocessing
該研究設(shè)計(jì)了一種用于二硫鍵交聯(lián)聚天冬氨酸(PASP-SS)水凝膠的光控釋藥系統(tǒng),在外部光源的刺激下,根據(jù)需要在時(shí)間和空間上釋放截留藥物的能力提高藥物利用率、優(yōu)化治療、減少毒性和副作用。研究使用巨哥科技紅外熱像儀觀測(cè)不同功率密度的光/不同PtNPs含量條件下,溶液溫度隨時(shí)間的變化情況:Temperatures were recorded using an infrared camera (Magnity Electronics, China) to evaluate the photothermal efect of PtNPs-ProK.

15. Preparation and in vitro evaluation of doxorubicin loaded alendronate modified hollow gold nanoparticles for bone-targeted chemo-photothermal therapy,2020年發(fā)表于Materials Express
該研究設(shè)計(jì)一種具有光熱效應(yīng)的骨靶向納米載體,以實(shí)現(xiàn)化學(xué)光熱療法(CPT),使光熱劑和化學(xué)藥物的使用量能夠靶向骨腫瘤。研究使用巨哥科技紅外熱像儀測(cè)量激光照射后HGNPs/HGNPs-ALN和PBS的溫度變化情況,驗(yàn)證其光熱傳導(dǎo)能力:the temperature was recorded every other minute by infrared thermal imager (Magnity Electronics, China).

16. TCPP-Isoliensinine Nanoparticles for Mild-Temperature Photothermal Therapy,發(fā)表于International Journal of Nanomedicine
該研究設(shè)計(jì)了一種新型的TCPP-Iso復(fù)合納米粒子,用于乳腺癌的協(xié)同治療,可有效抑制癌細(xì)胞活性并對(duì)周?chē)】到M織的熱損傷降至低谷。研究使用巨哥科技紅外熱像儀觀測(cè)在650 nm激光照射下,不同濃度的TCPP-Iso復(fù)合NPs的溫度變化:The evolution of temperatures was recorded by using infrared thermal camera (Magnity Electronics, China).

17. Unexpected high photothemal conversion efficiency of gold nanospheres upon grafting with two-photon luminescent ruthenium(II) complexes: A way towards cancer therapy,2015年發(fā)表于Biomaterials,ELSEVIER
該研究研制釕(II)多吡啶配合物可顯著提高金納米球的雙光子發(fā)光(PTL)強(qiáng)度和光熱療法(PTT)效率,成功用于實(shí)時(shí)熒光成像引導(dǎo)的活癌細(xì)胞PTT。研究使用巨哥科技紅外熱像儀觀測(cè)808nm的激光照射下,納米顆粒溶液中光誘導(dǎo)的溫度變化。Light-induced temperature change in the solutions was collected by using a thermal camera (MAG30, Magnity Electronics, Thermal Imaging Expert).

18. Water-Soluble Hyaluronic Acid-Hybrided Polya ni li ne Nanoparticles for Effectively Targeted Photothermal Therapy,2014年1月發(fā)表于Journal of Materials Chemistry B
該研究開(kāi)發(fā)了一種水溶性透明質(zhì)酸雜化聚苯胺納米顆粒(HAPANI NPs),作為光熱療法(PTT)的納米平臺(tái),具有CD44介導(dǎo)的癌細(xì)胞的靶向特異性。研究使用巨哥科技紅外熱像儀觀測(cè)808nm的激光照射下,HA-PANI NPs溶液和純水在不同時(shí)間段的溫度變化:The photothermal images of pure water and HA-PANI NPs in aqueous solution were taken by Infrared camera (MAG30, Magnity Electronics, China) in conjunction with the 808 nm laser.

以上為生命科學(xué)領(lǐng)域使用巨哥科技熱像儀開(kāi)展的部分細(xì)胞靶向研究工作。巨哥科技致力于為前沿科學(xué)研究領(lǐng)域提供科學(xué)級(jí)精準(zhǔn)測(cè)溫?zé)嵯駜x,助力科研人員取得優(yōu)秀的科研成果,歡迎聯(lián)系咨詢(xún)。
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