Paclitaxel

MCE 國(guó)際站：Paclitaxel

品牌：MedChemExpress (MCE)

貨號(hào)：HY-B0015

CAS：33069-62-4

中文名稱(chēng)：紫杉醇

Synonyms：紫杉醇

純度：99.97%

存儲(chǔ)條件：4°C，避光保存 *溶劑中：-80°C，6 個(gè)月；-20°C，1 個(gè)月（避光保存）

運(yùn)輸條件：美國(guó)大陸的室溫；其他地方可能有所不同。

產(chǎn)品活性：Paclitaxel 是一種天然抗腫瘤藥，可穩(wěn)定微管蛋白 (tubulin) 的聚合。Paclitaxel 可導(dǎo)致有絲分裂停滯和誘導(dǎo)細(xì)胞凋亡 (apoptosis)，最終導(dǎo)致細(xì)胞死亡。Paclitaxel 還可誘導(dǎo)細(xì)胞自噬 (autophagy)。

生物活性：紫杉醇是一種天然存在的抗腫瘤劑，可穩(wěn)定微管蛋白聚合。紫杉醇可引起有絲分裂停滯和凋亡細(xì)胞死亡。紫杉醇還誘導(dǎo)自噬^[1][2]。 IC50 和目標(biāo)：IC50：4 nM（微管）

體外：Paclitaxel (20 nM；48 h) 誘導(dǎo)程序性細(xì)胞死亡，并在細(xì)胞周期的 G2/M 期存在阻滯[1]。 Paclitaxel (20 nM；48 hours) 誘導(dǎo) p53 水平的持續(xù)增加[1]。 MCE尚未獨(dú)立證實(shí)這些方法的準(zhǔn)確性。僅供參考。

體內(nèi)：Paclitaxel (1 -20 mg/kg；腹腔注射；1次/2天，共5個(gè)周期) 在低 Paclitaxel 組明顯誘導(dǎo)肝轉(zhuǎn)移，對(duì)原發(fā)腫瘤生長(zhǎng)影響不大[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50 & Target：Traditional Cytotoxic Agents

熱銷(xiāo)產(chǎn)品：2'-Deoxycytidine  | Isocitric acid  | DOTA-GA(tBu)4  | Acitretin  | PD-1/PD-L1-IN-29  | Z-Nle-Lys-Arg-AMC (acetate)  | Bafetinib  | OTSSP167  | L-Thyroxine (sodium salt pentahydrate)  | Ticlopidine

Trending products：Recombinant Proteins  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Oligonucleotides

參考文獻(xiàn)：

[1]. Choi YH, et al. Paclitaxel-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells. Oncol Rep. 2012 Dec;28(6):2163-9.
[2]. Dziadyk JM, et al. Paclitaxel-induced apoptosis may occur without a prior G2/M-phase arrest. Anticancer Res. 2004 Jan-Feb;24(1):27-36.
[3]. Li Q, et al. Low doses of paclitaxel enhance liver metastasis of breast cancer cells in the mouse model. FEBS J. 2016 Aug;283(15):2836-52.
[4]. Pan Z, et al. Paclitaxel attenuates Bcl-2 resistance to apoptosis in breast cancer cells through an endoplasmic reticulum-mediated calciumrelease in a dosage dependent manner. Biochem Biophys Res Commun. 2013 Feb 13. pii: S0006-291X(13)00259-3.
[5]. Cadamuro M, et al. Low dose paclitaxel reduces S100A4 nuclear import to inhibit invasion and hematogenous metastasis of cholangiocarcinoma. Cancer Res. 2016 Jun 21.
[6]. Li Q, et al. Low doses of paclitaxel enhance liver metastasis of breast cancer cells in the mouse model. FEBS J. 2016 Jun 16.
[7]. Yilmaz E, et al. Sensory neuron subpopulation-specific dysregulation of intracellular calcium in a rat model of chemotherapy-induced peripheral neuropathy. Neuroscience. 2015 Aug 6;300:210-8.
[8]. Jing C, et al. E7080 enhances the antitumor effects of paclitaxel in anaplastic thyroid cancer. Am J Cancer Res. 2017 Apr 1;7(4):903-912.