孕激素受體（PR）

廣州健侖生物科技有限公司

人孕激素受體（PR）作為配體激活的轉錄因子，是類固醇激素受體家族的一員。PR有兩個異構體PR-A(94kDa)和PR-B(114kDa)。雖然它們的轉錄活性相反，但它們的DNA和配體結合親和力相似。PR-B是孕激素敏感基因的激活劑，而PR-A則抑制PR-B功能。作為乳腺癌內(nèi)分泌治療參考依據(jù)，PR與ER、HER-2已經(jīng)作為乳腺癌患者的研究檢測項目。

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【產(chǎn)品介紹】

細胞定位：細胞核

克隆號：Y85

同型：IgG

適用組織：石蠟/冰凍

陽性對照：乳腺癌

抗原修復：熱修復（EDTA）

抗體孵育時間：30-60min

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】     歐

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

致力于再生細胞并培養(yǎng)新組織來治療衰竭性損傷和疾病(如帕金森病、心臟病和脊髓損傷)的研究人員，所面臨的一個主要挑戰(zhàn)是，創(chuàng)建一種簡單、有效和無毒性的方法，來控制到特定細胞譜系的分化。Lee及其羅格斯大學、日本京都大學的同事們，發(fā)明了一種平臺，他們稱之為NanoScript，對于基因表達領域的研究人員來說，這是一個重要的突破。基因表達是指細胞在生命過程中，把儲存在DNA順序中遺傳信息經(jīng)過轉錄和翻譯，轉變成具有生物活性的蛋白質(zhì)分子，對于通過干細胞治療的組織發(fā)育過程是很重要的。
干細胞具有很大的潛力應用于各種醫(yī)學治療，因為它們能夠培養(yǎng)整個身體的組織。在許多組織中，干細胞作為一種內(nèi)部修復系統(tǒng)，具有幾乎無限分裂和補充其他細胞的能力。
轉錄因子(TF)蛋白質(zhì)是基因表達的主要調(diào)控因子。TF蛋白在調(diào)控干細胞分化過程中發(fā)揮重要的作用。雖然有些人試圖制造行使天然轉錄因子功能的合成分子，但NanoScript是*個能夠與內(nèi)源DNA相互作用的納米材料TF蛋白質(zhì)。Lee關于NanoScript的這項研究，發(fā)表在zui近的美國化學學會期刊《ACS Nano》。該研究是由美國國立衛(wèi)生研究院(NIH)資助支持。

A major challenge for researchers working on regenerating cells and developing new tissue to treat failing lesions and diseases such as Parkinson's disease, heart disease, and spinal cord injury is creating a simple, effective, and non-toxic approach , To control the differentiation of specific cell lineages. Lee and his colleagues at Rutgers University and Kyoto University in Japan invented a platform that they call NanoScript, an important breakthrough for researchers in the field of gene expression. Gene expression refers to the cells in the life process, stored in the DNA sequence of genetic information through transcription and translation, into a biological activity of protein molecules, through the stem cell treatment of tissue development is very important.
Stem cells have great potential for use in a variety of medical treatments because they are capable of developing tissue throughout the body. In many tissues, stem cells act as an internal repair system that has the ability to divide and replenish other cells almost indefiniy.
Transcription factor (TF) proteins are the major regulatory elements of gene expression. TF protein plays an important role in the regulation of stem cell differentiation. Although some people try to make synthetic molecules that perform the function of natural transcription factors, NanoScript is the first TF protein of nanomaterials that interacts with endogenous DNA. Lee's research on NanoScript was published in the recent ACS Nano Journal. The study was funded by the National Institutes of Health (NIH).