美國Seracare陽性血清性能盤（Performance Panels）

廣州健侖生物科技有限公司

SeraCare Life Sciences公司主要在美國、歐洲和亞洲提供促進人類和動物診斷和治療學的探索、開發和生產的產品和服務。其業務分為兩個部分：診斷和生物制藥產品和生物服務。診斷和生物制藥產品部門生產和銷售診斷和控制面板產品，用于測試傳染性疾病的臨床實驗室及員工培訓和能力測試。生物服務部門提供生物銀行、來樣加工和測試服務。

美國SeraCare收購BBI公司，即原BBI血清盤已經改名為SeraCare血清盤。

其產品包括有：傳染病陽性質控品、疾病標準品、細菌陽性質控品、人血清白蛋白、人伽馬球蛋白、牛血清白蛋白、血清盤、人血漿、人血清。

SeraCare的血清盤包括：HIV-1轉化盤、HIV性能盤、HBV轉化盤、HBV性能盤、HCV轉化盤、HCV性能盤、弓形蟲性能盤、線性盤和質控盤等等。

我司還提供其它進口或國產試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團菌、化妝品檢測、食品安全檢測等試劑盒以及日本生研細菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產品。

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美國Seracare陽性血清性能盤（Performance Panels）

HIV性能盤、HBV性能盤、HCV性能盤、弓形蟲性能盤、抗EB病毒多價性能盤、、人類嗜T細胞病毒I/II型多價性能盤、巨細胞病毒多價性能盤、抗甲肝多價性能盤、細小病毒B19多價性能盤、梅毒性能盤。

美國Seracare

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【公司名稱】 廣州健侖生物科技有限公司

【市 場 部】    楊永漢

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【騰訊Q Q】 2042552662

【公司地址】 廣州清華科技園創新基地番禺石樓鎮創啟路63號二期2幢101-103室

APOEε4等位基因是zui常見的阿茲海默癥遺傳風險基因。不過空氣污染物與阿茲海默癥之間的關系的卻很少有人注意。而墨西哥城是一個快速發展伴隨嚴重環境污染的城市，800萬城市生活的兒童都不得不每天暴露在PM2.5超標的環境中。為了評估APOEε4健康兒童在認知，嗅覺和代謝性腦指數方面是否受到空氣污染物影響，研究人員對50個生活在墨西哥城市的13.4±4.8歲攜帶APOEε3或者APOEε4的孩子進行了韋氏兒童智力量表(WISC-R)評分和氣味鑒別實驗，同時用質子磁共振測量海馬，腦橋，額葉頂葉白質的腦代謝產物。如預測一樣，攜帶APOEε4的孩子右額葉白質的關鍵代謝產物比例比APOEε3的兒童要少，對肥皂的臭味鑒別困難，言語和智商平分低于平均分，并且顯現出短期記憶和對關注的顯著遞減。
研究人員認為是持續暴露于城市空氣污染造成的認知不佳，膠質細胞和神經元代謝的改變。居住在嚴重污染的城市，APOEε4的綜合影響可能導致神經退行性變化的加速?？諝馕廴臼且粋€嚴重的公共衛生問題，暴露于空氣中污染物的濃度達到或超過現行標準已經被證實與神經炎癥和神經病理學相關。在美國，有2億人居住在臭氧和細顆粒物污染物超標的環境中。而且已經有證據顯示顆粒污染物與因中風，心血管和呼吸系統疾病的死亡率增加有明顯關系。而生活在像墨西哥大城市兒童的相關的健康問題更多。
目前迫切需要有一個更深入的研究證明APOEε4和空氣污染的相互作用能影響兒童的大腦，或許將來能提供對阿爾茨海默氏病的預防*的新提示。
近日，來自英國的科學家在生物學期刊molecular and Cellular biology在線發表了他們關于RNA聚合酶III調控巨噬細胞功能的研究進展。
研究人員指出，腫瘤微環境中的炎癥具有許多促癌癥發展效應。特別是腫瘤相關巨噬細胞(TAM)能夠產生許多細胞因子，促進惡性腫瘤細胞存活，血管生成以及轉移維持腫瘤生長。腫瘤相關巨噬細胞內細胞因子的合成與蛋白質合成過程緊密相關，而蛋白質的翻譯過程又依賴于RNA聚合酶III轉錄形成的眾多tRNA。因此研究RNA聚合酶III對腫瘤相關巨噬細胞的功能發揮有何影響具有重要意義。

The APOEε4 allele is the most common genetic risk factor for Alzheimer's disease. However, little attention has been paid to the relationship between air pollutants and Alzheimer's disease. Mexico City is a rapidly developing city with severe environmental pollution, and 8 million children living in cities have to be exposed to excessive levels of PM2.5 every day. To assess whether APOEε4 healthy children were affected by air pollutants in terms of cognition, olfactory and metabolic brain indices, the researchers performed Wechsler’s inligence on 50 children with APOEε3 or APOEε4 at ages of 13.4±4.8 years living in Mexican cities. Table (WISC-R) scores and odor identification experiments were performed. Proton magnetic resonance was used to measure brain metabolites in the white matter of the hippocampus, pons, and frontal lobe. As predicted, the proportion of key metabolites in the right frontal white matter of children with APOEε4 is lower than that of APOEε3 children. It is difficult to identify soap odors, scores of speech and IQ are lower than average, and short-term memory and attention are shown. Significantly decreasing.
The researchers believe that the continuous exposure to urban air pollution caused poor perception, changes in the metabolism of glial cells and neurons. Living in a heavily polluted city, the combined effects of APOEε4 may lead to an acceleration of neurodegenerative changes. Air pollution is a serious public health problem. Exposure to airborne pollutant concentrations that meet or exceed current standards has been shown to be related to neuroinflammation and neuropathology. In the United States, 200 million people live in environments with excessive ozone and fine particulate matter. Moreover, there has been evidence that particulate pollutants are significantly associated with increased mortality from stroke, cardiovascular and respiratory diseases. There are more health problems related to children living in major cities in Mexico.
There is an urgent need for a more in-depth study to prove that the interaction between APOE ε4 and air pollution can affect children's brains, and may provide new and unprecedented tips for the prevention of Alzheimer's disease in the future.
Recently, scientists from the United Kingdom published their latest research on RNA polymerase III regulating macrophage function in the online journal of molecular and cellular biology.
The researchers pointed out that inflammation in the tumor microenvironment has many cancer-promoting effects. In particular, tumor-associated macrophages (TAMs) are capable of producing many cytokines, promoting the survival of malignant tumor cells, and angiogenesis and metastasis to maintain tumor growth. The synthesis of cytokines in tumor-associated macrophages is closely related to the process of protein synthesis, and the process of protein translation depends on the numerous tRNAs that RNA polymerase III transcribes. Therefore, it is of great significance to study the effect of RNA polymerase III on the function of tumor-associated macrophages.